205例子痫前期史患者再妊娠临床特点  

Characteristics of the current pregnancy in 205 women with preeclampsia history

作　　者：钟西文 潘宁萍[2] 吴高义 ZHONG Xiwen;PAN Ningping;WU Gaoyi(Wenzhou Central Hospital, Wenzhou, Zhejiang Province,325000;Obstetrics and Gynecology Hospital affiliate to School of Medicine, Zhejiang University)

机构地区：[1]浙江省温州市中心医院,325000 [2]浙江大学医学院附属妇产科医院

出　　处：《中国计划生育学杂志》2021年第10期2173-2176,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨子痫前期患者再妊娠的临床特点及再发危险因素。方法:回顾性分析2010年1月—2019年12月本院分娩、既往妊娠有子痫前期病史孕妇205例临床资料。结果:205例中有75例(36.6%)再次发生子痫前期。单因素分析发现肥胖、高龄、前次子痫前期为重度子痫前期、早发型子痫前期、妊娠高血压综合征与子痫前期再发相关;logistic回归分析,肥胖、高龄、前次妊娠为早发型子痫前期是子痫前期再发的高危因素,小剂量阿司匹林可以预防子痫前期再发(P<0.05)。低分子肝素联合阿司匹林较单用阿司匹林或低分子肝素者可有效延长妊娠孕周,提高新生儿出生体重(P<0.05)。结论:对于高龄、肥胖及前次妊娠为早发型子痫前期的孕妇应做好子痫前期再发的监测及临床预防,采取低分子肝素及阿司匹林药物干预可延长孕妇孕周、提高新生儿出生体重,降低早产率。Objective:To evaluate the characteristics of pregnancy again of women with preeclampsia history,and to study the risks factors of recurrent preeclampsia.Methods:A retrospective study was performed on the clinical data of 205 pregnant women with preeclampsia history from January 2010 to December 2019.Results:There were 75(36.6%)women with preeclampsia recurred in 205 women.Univariate analysis showed that obesity,advanced age,severe preeclampsia,early onset preeclampsia,and HELLP syndrome during previous pregnancy were associated with the recurrence of preeclampsia.Logistic regression analysis showed that obesity,advanced age,and early onset preeclampsia during previous pregnancy were the risk factors of the recurrence of preeclampsia.And low-dose aspirin could prevent recurrence of preeclampsia(P<0.05).Low molecular weight heparin combined with aspirin had prolonged the gestational weeks and increased the birth weight of newborns when compared with aspirin or low molecular weight heparin used alone(P<0.05).Conclusion:The effective monitoring and preventive measures should be conducted in pregnant women with obese,advance age,or history of early-onset preeclampsia for avoiding recurrent preeclampsia.Aspirin combined with low-molecular-weight heparin can prolong the gestational weeks and improve neonatal birth weight.

关 键 词：子痫前期史 再发风险 小剂量阿司匹林 低分子肝素 预防 

分 类 号：R714.244[医药卫生—妇产科学]