梅毒妊娠孕妇Th17、IL-17与不良妊娠结局及预测意义  

The correlation and predictive value of levels of the interleukin-17 and interleukin 17 of T cell subsets of pregnant women with syphilis for their adverse pregnancy outcomes

作　　者：许宗严[1] 胡瑞娟[1] 帅俊[1] 石建新[1] 李频[1] 邱莉霞[1] XU Zongyan;HU Ruijuan;SHUAI Jun;SHI Jianxin;LI Pin;QIU Lixia(Futian District Chronic Disease Control Hospital, Shenzhen, Guangdong Province, 518000)

机构地区：[1]深圳市福田区慢性病防治院,518000

出　　处：《中国计划生育学杂志》2021年第10期2185-2188,共4页Chinese Journal of Family Planning

基　　金：深圳市福田区卫生公益性科研项目(FTWS2018078)。

摘　　要：目的:探讨白细胞介素(IL)-17、辅助性T细胞17(Th17)与梅毒妊娠孕妇不良妊娠结局及诊断意义。方法:选取2016年1月—2019年12月本地区筛查出梅毒妊娠孕妇244例,根据梅毒血清TRUST滴度水平分为低滴度组110例、高滴度组14例;健康孕妇120例为对照组。测定孕妇Th17、IL-17水平,分析梅毒妊娠孕妇不良妊娠结局影响因素及Th17、IL-17检测诊断意义。结果:Th17、IL-17水平梅毒妊娠孕妇均高于对照组(P<0.01),但高滴度组与低滴度组无差异(P>0.05)。发生不良妊娠结局梅毒妊娠孕妇(22例,17.7%)高于对照组(2例,1.7%)(P<0.05);Th17、IL-17均是梅毒妊娠孕妇发生不良妊娠结局的独立危险因素(P<0.05);预测梅毒孕妇发生不良妊娠结局曲线下面积(AUC)Th17为0.964、IL-17为0.975。结论:梅毒妊娠孕妇外周血Th17细胞及血清IL-17水平均高于健康孕妇,不良妊娠结局发生率高于健康孕妇,Th17、IL-17水平对梅毒妊娠孕妇不良妊娠结局有较高预测意义。Objective:To explore the correlation and diagnostic value of interleukin-17(IL-17)and interleukin 17 levels of T cell subsets(Th17)of the pregnant women with syphilis for their adverse pregnancy outcomes.Methods:244 pregnant women with syphilis from January 2016 to December 2019 were selected and were divided into group A(110 women with low titer of serum TRUST)and group B(14 women with high titer of serum TRUST),and 120 healthy pregnant women were selected in control group.The influencing factors of adverse pregnancy outcomes of the pregnant women with syphilis were analyzed,and the diagnostic value of Th17 and IL-17 levels were also analyzed.Results:The levels of Th17 and IL-17 of the women in group A and group B were significant higher than those of the women in the control group(P<0.01),but which of the women had no significant different between group B and group A(P>0.05).The incidence of adverse pregnancy outcomes(22 cases,17.7%)of the women in group A and group B was significant higher than that(2 cases,1.7%)of the women in the control group(P<0.05).The Th17 and IL-17 levels were the independent risk factors of adverse pregnancy outcomes of the pregnant women with syphilis(P<0.05).AUC of Th17 level of the women for predicting their adverse pregnancy outcome was 0.964,and which of IL-17 level was 0.975.Conclusion:The levels of Th17 cells in peripheral blood and serum IL-17 of the pregnant women with syphilis are significant higher than those of the healthy pregnant women,and the incidence of adverse pregnancy outcomes of the pregnant women with syphilis is also significant higher than that of the healthy pregnant women.The levels of Th17 and IL-17 have higher diagnostic value for adverse pregnancy outcomes of the pregnant women with syphilis.

关 键 词：梅毒妊娠孕妇 白细胞介素-17 辅助性T细胞17 不良妊娠结局 预测 

分 类 号：R759.15[医药卫生—皮肤病学与性病学]