ARID1A、PIK3CA表达与子宫内膜异位症相关卵巢癌关系及发病因素分析  

The relationship between the expression of ARID1A and PIK3CA and the occurrence of ovarian cancer associated with endometriosis,and the risk factors

作　　者：高秀娟[1] 张雅丽[1] 庄新荣[1] 张桂香[1] GAO Xiujuan;ZHANG Yali;ZHUANG Xinrong;ZHANG Guixiang(The Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, 067000)

机构地区：[1]承德医学院附属医院,067000

出　　处：《中国计划生育学杂志》2021年第10期2200-2203,2207,共5页Chinese Journal of Family Planning

摘　　要：目的:研究子宫内膜异位症相关卵巢癌者AT丰富结合域1A基因(ARID1A)、磷脂酰肌醇-3-激酶催化亚单位α基因(PIK3CA基因)表达及发病危险因素。方法:以本院2016年1月—2020年5月收治的子宫内膜异位症患者85例作为研究对象,其中子宫内膜异位症相关性卵巢癌(EAOC)组45例,卵巢-子宫内膜异位症(OEM)组40例,非子宫内膜异位症相关性卵巢癌患者80例作为对照(non-EAOC组),比较3组患者的ARID1A、PIK3CA表达差异,分析RID1A、PIK3CA表达水平对子宫内膜异位症相关卵巢癌的诊断效能及发病危险因素。结果:3组患者的ARID1A、PIK3CA表达水平从高到低依次为EAOC组、non-EAOC组、OEM组(P<0.05)。ARID1A联合PIK3CA诊断子宫内膜异位症相关卵巢癌的灵敏度(97.8%)高于单独检测,ARID1A、PIK3CA临界值分别为44.56、40.06;患者年龄大、绝经、卵泡刺激素高、盆腔疼痛、腹部不适、阴道出血及初潮年龄小均为子宫内膜异位症相关卵巢癌发病的独立危险因素。结论:子宫内膜异位症相关卵巢癌者者ARID1A、PIK3CA表达升高,提示临床诊断时更加关注可能因素及早干预,提升疾病的确诊率。Objective:To study the relationship between the expression rules of ARID1A and PIK3CA of the patients and the occurrence of their ovarian cancer associated with endometriosis,and to study the risk factors affecting the ovarian cancer of the patients their ovarian cancer associated with endometriosis.Methods:85 patients with endometriosis selected as the research objects from January 2016 to may 2020,which included 45 patients with ovarian cancer associated with endometriosis in group A,40 patients with endometriosis of ovarian in group B,and 80 patients without ovarian cancer associated with endometriosis in group C.The expression levels of ARID1A and PIK3CA of the patients were compared among the three groups.The diagnostic efficacy of the levels of ARID1A and PIK3CA of the patients for their endometriosis related ovarian cancer was analyzed,and the risk factors of endometriosis related ovarian cancer of the patients were also analyzed.Results:The expression levels of ARID1A and PIK3CA of the patients in group A were the highest,and then followed by those of the patients in group C,and those of the patients in group B were the lowest(P<0.05).The sensitivity(97.8%)of the combined levels of ARID1A and PIK3CA of the patients for diagnosing endometriosis associated ovarian cancer was significant higher than that of ARID1A level or PIK3CA level alone.The critical values of ARID1A and PIK3CA expression levels were 44.56 and 40.06,respectively.Multivariate analysis had showed that older age,menopause,high level of follicle stimulating hormone,pelvic pain,abdominal discomfort,vaginal bleeding,and young age of menarche were the independent risk factors of the occurrence of ovarian cancer associated with endometriosis.Conclusion:The expressions of ARID1A and PIK3CA of the ovarian cancer associated with endometriosis of the patients increase.It suggests that the possible factors in clinical diagnosis and early intervention should be paid more attention to for improving the diagnosis rate of the ovarian cancer associated wi

关 键 词：子宫内膜异位症 相关性卵巢癌 AT丰富结合域1A基因 磷脂酰肌醇-3-激酶催化亚单位α基因 危险因素 

分 类 号：R711.71[医药卫生—妇产科学] R737.31[医药卫生—临床医学]