糖皮质激素联合诺雷德治疗子宫内膜异位症腹腔镜术后疗效及对雌激素水平、妊娠影响  

Effect of glucocorticoid combined with norade for treating women with endometriosis after laparoscopic surgery and its influence on their estrogen level and subsequent pregnancy

作　　者：毛薇 张昀 熊芳 MAO Wei;ZHANG Yun;XIONG Fang(Wuxi Matemity and Child Health Care Hospital Affiliated to Nanjing Medical University,Wuxi, Jiangsu Province,214000)

机构地区：[1]南京医科大学附属无锡妇幼保健院,214000

出　　处：《中国计划生育学杂志》2021年第11期2288-2291,2296,共5页Chinese Journal of Family Planning

摘　　要：目的:探究腹腔镜术后糖皮质激素联合诺雷德对子宫内膜异位症(EMT)疗效、雌激素水平及妊娠影响。方法:选取2017年5月-2019年5月就诊于本院的EMT患者100例,随机数字表法分为对照组50例和观察组50例,对照组行腹腔镜术后诺雷德治疗,观察组在对照组基础上联合糖皮质激素治疗,连续治疗6个月。比较两组临床疗效、雌激素水平、妊娠率及复发率。结果:临床总有效率观察组(96.0%)高于对照组(80.0%)(P<0.05);治疗后,两组雌激素水平降低且观察组降低幅度大于对照组(P<0.05);术后1年内观察组妊娠率(74.0%)高于对照组(52.0%),复发率(2.0%)低于对照组(10.0%)(P<0.05)。结论:腹腔镜术后糖皮质激素联合诺雷德治疗EMT,不仅可显著提高临床疗效,改善雌激素水平,而且还能够提高妊娠率,降低复发率。Objective:To explore glucocorticoid combined with norade for treating women with endometriosis(EMT)after laparoscopic surgery,and to study its influence on their estrogen level and latter pregnancy.Methods:100 women with EMT were selected and divided into control group and observation group(50 cases in each group)according to the random number table method from May 2018 to may 2019.The women in the control group were treated with norade after laparoscopic surgery for 6 months,and the women in the observation group were treated with glucocorticoid combined with norade for 6 months.The clinical efficacy,estrogen level,pregnancy rate,and recurrence rate of EMT of the women were compared between the two groups.Results:The total clinical effective rate(96.0%)of the women in the observation group was significantly higher than that(80.0%)of the women in control group(P<0.05).After treatment,the estrogen level of the women in both groups had decreased significantly,and the decreasing degree of the women in the observation group was significantly more than that of the women in the control group(P<0.05).The pregnancy rate(74.0%)of the women within 1 year after operation in the observation group was significantly higher than that(52.0%)of the women in the control group,but the recurrence rate of EMT(2.0%)of the women within 1 year after operation in the observation group was significantly lower than that(10.0%)of the women in the control group(P<0.05).Conclusion:Glucocorticoid combined with norade for treating women with EMT after laparoscopic surgery can not only significantly improve the clinical efficacy and estrogen level,but also can increase the latter pregnancy rate and can reduce the recurrence rate of EMT.

关 键 词：子宫内膜异位症 腹腔镜手术 糖皮质激素 诺雷德 临床疗效 雌激素 再妊娠 复发 

分 类 号：R71[医药卫生—妇产科学]