妊娠期糖尿病患者血清丙二醛、趋化素水平与围产结局  

Relationship between the levels of the serum malondialdehyde and chemokine of women with gestational diabetes mellitus and their perinatal outcomes

作　　者：俞梦春 米娟 YU Mengchun;MI Juan(Affiliated Hospital of Yan 'an University, Shannxi Province, 716000;Yan 'an Branch of Third Hospital of Beijing Medical University(Yan 'an Hospital of Traditional Chinese Medicine))

机构地区：[1]延安大学附属医院,716000 [2]北医三院延安分院(延安市中医院)

出　　处：《中国计划生育学杂志》2021年第11期2408-2411,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨妊娠期糖尿病(GDM)患者血清丙二醛(MDA)、趋化素水平与围产结局关系。方法:选择2017年1月-2020年8月本院分娩的GDM患者108例和健康孕妇108例进行回顾性分析,获取MDA、趋化素水平及围产结局,根据围产结局分为不良组和无不良组,分析不良围产结局的高危因素。结果:随着孕周增大两组孕妇MDA、趋化素、FBG、IRI水平升高,且GDM组高于健康组(P<0.05);GDM组剖宫产、巨大儿、新生儿低血糖、早产、妊娠期高血压发生率及不良围产结局总发生率(60.2%)均高于健康组(18.5%),GDM组不良结局孕妇MDA、趋化素、FBG、IRI水平高于无不良结局孕妇(P<0.05)。MDA、趋化素、IRI水平升高是GDM患者发生不良妊娠结局的独立影响因素(P<0.05)。结论:GDM患者机体存在明显氧化应激反应,血清MDA、趋化素水平异常上调增加了患者剖宫产、巨大儿、新生儿低血糖、早产、妊娠期高血压发生率,是不良围产结局发生的高危因素。Objective:To investigate the relationship between the levels of serum malondialdehyde(MDA)and chemokine of women with gestational diabetes mellitus(GDM)and their perinatal outcomes.Methods:108 women with GDM(in study group)and 108 healthy pregnancy women(in control group)from January 2017 to August 2020 were analyzed retrospectively.The levels of MDA and chemokine of the women in the two groups were detected.The women in the study were further divided into group A(women with adverse outcomes)and group B(women without adverse outcomes)according to their perinatal outcomes.The risk factors of adverse perinatal outcomes were analyzed.Results:The levels of MDA,chemokine,FBG,and IRI of the women in the two groups had increased with the increase of their gestational weeks,and those of the women in the study group were significant higher than those of the women in the control group(P<0.05).The incidence(60.2%)of total adverse perinatal outcomes,such as cesarean section,macrosomia,neonatal hypoglycemia,preterm delivery,and gestational hypertension of the women in the study group was significant higher than that(18.5%)of the women in the control group.In the study group,the levels of MDA,chemokine,FBG,and IRI of the women in group A were significantly higher than those of the women in group B(P<0.05).The increase of MDA,chemokine,and IRI levels of the women with GDM were the independent influencing factors of the adverse pregnancy outcomes(P<0.05).Conclusion:The women with GDM have obvious oxidative stress reaction,and their abnormal up-regulation of serum MDA and the chemokine levels increase the risk of cesarean section,macrosomia,neonatal hypoglycemia,premature delivery,and gestational hypertension,which are all the high-risk factors of adverse perinatal outcomes.

关 键 词：妊娠期糖尿病 丙二醛 趋化素 围产结局 高危因素 

分 类 号：R714.256[医药卫生—妇产科学]