子痫前期患者血清HSP70表达与不良妊娠结局  

Expression of serum heat shock protein 70 and adverse pregnancy outcomes of pregnant women with preeclampsia

作　　者：秦新蕾 黄敏敏[1] 李大众 QIN Xinlei;HUANG Minmin;LI Dazhong(The Second People's Hospital of Lianyungang, Jiangsu Province, 222000)

机构地区：[1]江苏省连云港市第二人民医院,222000

出　　处：《中国计划生育学杂志》2021年第11期2428-2431,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨子痫前期患者血清热休克蛋白70(HSP70)表达与不良妊娠结局。方法:选择2017年10月-2019年10月在本院分娩的孕期诊断为子痫前期产妇60例,其中子痫前期组(n=35)、重度子痫前期组(n=25例);规律产前检查健康孕产妇40例为对照组。分析比较3组产妇血清HSP70水平及子痫前期患者与不良妊娠结局的相关性。结果:血清HSP70水平重度子痫前期组(5.47±2.16 ng/ml)最高,子痫前期组(2.78±0.94 ng/ml)次之,对照组(0.94±0.43 ng/ml)最低,产妇胎儿生长受限、早产、产后出血、新生儿窒息、胎儿窘迫发生率各组依次降低(均P<0.05)。高血清HSP70水平产妇胎儿生长受限、早产、产后出血、新生儿窒息、胎儿窘迫不良妊娠结局发生率增加(P<0.05)。结论:子痫前期患者血清HSP70水平升高且随病情加重而升高,高血清HSP70水平表达者不良妊娠结局发生升高。Objective:To investigate the expression of serum heat shock protein 70(HSP70)and the adverse pregnancy outcomes of pregnant women with preeclampsia.Methods:A total of 60 pregnant women with preeclampsia were selected,and were divided into group A(35 women with preeclampsia)and group B(25 women with severe preeclampsia)from October 2017 to October 2019.Another 40 healthy pregnant women who underwent regular physical examinations were selected in group C during the same period.The serum HSP70 levels of the women were compared among the three groups.And the relationship between the serum HSP70 levels of the women and their adverse pregnancy outcomes was analyzed.Results:The serum HSP70 level of the women in group B(5.47±2.16 ng/ml)was the highest,then followed by that(2.78±0.94 ng/ml)of the women in group A,and that(0.94±0.43 ng/ml)of the women in group C was the lowest(P<0.05).The incidence of the rate of fetal growth restriction,preterm delivery,postpartum hemorrhage,neonatal asphyxia,or fetal distress of the women in group B,in group A,and group C had decrease in turn significantly(all P<0.05).The incidence of the rate of fetal growth restriction,preterm delivery,postpartum hemorrhage,neonatal asphyxia,or fetal distress of the women with high level of serum HSP70 was significantly than that of the women with low level of serum HSP70(P<0.05).Conclusion:The serum HSP70 level of the pregnant women with preeclampsia increases significantly,which increase as the disease worsen.The occurrences of adverse pregnancy outcomes of the women with high level of serum HSP70 also increase.

关 键 词：子痫前期 热休克蛋白70 不良妊娠结局 

分 类 号：R714.244[医药卫生—妇产科学]