胎儿生长受限与母血和脐血PLGF、IGF-1、Hcy、瘦素水平关系  

Relationship between the fetal growth restriction(FGR)and placental growth factor,insulin-like growth factor-1,homocysteine,and leptin in maternal and cord blood

作　　者：杨蕾[1] 李艳[1] 刘传娜 YANG Lei;LI Yan;LIU Chuanna(The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450052)

机构地区：[1]郑州大学第一附属医院,450052

出　　处：《中国计划生育学杂志》2021年第11期2449-2452,共4页Chinese Journal of Family Planning

基　　金：河南省高等学校重点科研项目(20A320028);河南省卫生健康委员会项目(豫卫科教函[2020]13号)。

摘　　要：目的:研究胎儿生长受限(FGR)与母血和脐血胎盘生长因子(PLGF)、胰岛素样生长因子-1(IGF-1)、同型半胱氨酸(Hcy)、瘦素(Leptin)水平的关系。方法:回顾性收集本院2018年1月-2020年10月收治并分娩的100例FGR孕妇(FGR组)、同期正常分娩孕妇100例为对照组,收集孕妇一般资料和实验室检测指标,对比PLGF、IGF-1、Hcy、瘦素水平差异并分析以上因素与FGR的相关性。结果:分娩后,FGR组新生儿体重和胎盘均轻于对照组(P<0.05)。与对照组相比,FGR组母血血清PLGF、脐血PLGF、IGF-1、瘦素水平均降低,母血和脐血Hcy水平均升高(P<0.05)。FGR组新生儿体重、胎盘重量与母血IGF-1、瘦素无相关性,与母血PLGF、脐血PLGF、IGF-1、瘦素成正相关(P<0.001),与血清Hcy、脐血Hcy呈负相关(P<0.001)。结论:FGR的发生可与孕妇机体PLGF水平过低、Hcy水平过高有关。脐血IGF-1、瘦素水平也会影响胎儿生长发育状态。临床可根据各指标变化判断FGR,以降低不良妊娠结局风险。Objective:To study the relationship between the fetal growth restriction(FGR)of pregnant women and their levels of placental growth factor(PLGF),insulin-like growth factor-1(IGF-1),homocysteine(Hcy),and leptin in maternal and cord blood.Methods:100 pregnant women with FGR from January 2018 to October 2020 were selected in observation group retrospectively,and 100 normal pregnant women were selected in control group during the same period.The general data and laboratory test indicators of the women in the two groups were collected.The levels different of PLGF,IGF-1,Hcy,and leptin of the women were compared between the two groups,and the correlation between the different levels of PLGF,IGF-1,Hcy,and leptin of the women and their FGR occurrence was analyzed.Results:After delivery,the neonatal and placental weights of the women in the observation group were significantly lower than those of the women in the control group(P<0.05).The levels of PLGF in maternal serum,and the levels of PLGF,IGF-1,and leptin in umbilical cord blood of the women in the observation group were significantly lower than those of the women in the control group,while the levels of Hcy in maternal and umbilical cord blood were significantly higher(P<0.05).In the observation group,the neonatal and placental weights were no correlation with the levels of IGF-1 and leptin in maternal blood,but were positive correlation with the levels of PLGF in maternal blood,and the levels of PLGF,IGF-1 and leptin in umbilical blood(P<0.001),and had negatively correlated with the levels of Hcy in maternal serum and Hcy in umbilical cord blood(P<0.001).Conclusion:The high level of PLGF and low level of Hcy in maternal blood serum are closely related to FGR.The levels of IGF-1 and leptin in umbilical cord blood also affect the fetal growth and development.The occurrence of FGR can be confirmed according to the changes of various indicators in order to reduce the risk of adverse pregnancy outcomes in clinic.

关 键 词：胎儿生长受限 母血 脐带血 胎盘生长因子 胰岛素样生长因子 同型半胱氨酸 瘦素 相关性 

分 类 号：R714.5[医药卫生—妇产科学]