源自海洋裸孢壳属真菌Emericella sp.TJ414JZ-21的次级代谢产物  

Secondary metabolites of a marine derived fungus Emericella sp.TJ414JZ-21

作　　者：宦丽君 程灵[1] HUAN Lijun;CHENG Ling(School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China;Liyuan Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430077,Hubei,China)

机构地区：[1]华中科技大学同济医学院药学院,湖北武汉430030 [2]华中科技大学同济医学院附属梨园医院,湖北武汉430077

出　　处：《菌物学报》2022年第1期98-104,共7页Mycosystema

摘　　要：采用硅胶柱层析、中压反相柱层析、Sephadex LH-20凝胶柱层析以及半制备高效液相色谱等分离技术,从真菌Emericella sp.的大米发酵产物中分离得到了8个单体化合物,并利用波谱学方法结合文献数据对其结构进行了鉴定,分别为:asteltoxin(1)、asteltoxin B(2)、penicillide(3)、purpactin A(4)、tajixanthone hydrate(5)、mycophenolic acid(6)、trans-dehydrodiferulate dimethyl ester(7)、2,8-dihydroxy-1,3-dimethoxy-6-methylanthraquinone(8)。其中,化合物3和4均为首次从该属真菌中分离得到。Eight compounds were isolated from the fungus Emericella sp.Silica gel column chromatography,medium pressure reversed phase column chromatography(ODS),Sephadex LH-20,and semi-preparative HPLC were used for isolation and purification of these compounds.Their structures were determined by comparison of their spectroscopic data with those reported in the literatures.They were identified as asteltoxin(1),asteltoxin B(2),penicillide(3),purpactin A(4),tajixanthone hydrate(5),mycophenolic acid(6),trans-dehydrodiferulate dimethyl ester(7),and 2,8-dihydroxy-1,3-dimethoxy-6-methylanthraquinone(8).Compounds 3 and 4 were isolated from the genus Emericella for the first time.

关 键 词：裸孢壳属 次级代谢产物 分离纯化 结构鉴定 

分 类 号：Q936[生物学—微生物学]