极性界面对海藻酸钙凝胶单元形态与降解性能的影响  

Influence of polar interface on the morphology and degradation performance of calcium alginate gel units

作　　者：李瑜[1] 申永彬 卞平艳[1] 王建平[1] LI Yu;SHEN Yongbin;BIAN Pingyan;WANG Jianping(School of Mechanical and Power Engineering,He'nan Polytechnic University,Jiaozuo 454000,China)

机构地区：[1]河南理工大学机械与动力工程学院,焦作454000

出　　处：《复合材料学报》2022年第1期258-265,共8页Acta Materiae Compositae Sinica

基　　金：国家自然科学基金(31370999);河南省高校重点科研项目(18A460023)。

摘　　要：生物支架的降解直接影响其结构、功能及所装载细胞的存活率。以海藻酸钠为原料,氯化钙为交联剂,制备海藻酸钙水凝胶生物支架;通过交联剂溶剂中异丙醇(IPA)与去离子水(DW)比例的变化,获得不同极性条件的同轴反应流界面,从而影响海藻酸钙凝胶的凝胶单元聚集形态,考察界面极性对其降解进程的调控能力。结果表明,随着交联剂中IPA比例的增加,溶剂极性指数由9.0渐变至3.9;随着界面极性的减弱,所制备纤维的微观凝胶单元,越呈现有序性;有序而密实的凝胶单元形态减缓海藻酸盐纤维的降解速率,第5天DW基纤维支架的质量损失率为91.16%,而IPA纤维支架为73.86%;凝胶单元越致密,溶胀度越低,而溶胀平衡对降解进程有迟滞作用。The degradation of the bio-scaffold directly affects its structure,function and survival rate of the loaded cells.Sodium alginate as the raw material and calcium chloride as the cross-linking agent were used to prepare calcium alginate hydrogel bio-scaffold;by changing the ratio of iso-propyl alcohol(IPA)to deionized water(DW)in the crosslinking solvent,coaxial reaction flow interfaces with different polarity conditions were obtained,which affected the aggregation morphology of gel units of calcium alginate gel.The regulation ability of interface polarity on the degradation process of calcium alginate gel was investigated.The results show that the polarity index of the solvent changes from 9.0 to 3.9 with the increase of the proportion of IPA in the crosslinking agent;as the polarity of the interface decreases,the microscopic gel unit of the prepared fiber becomes more orderly;the degradation rate of alginate fibers is slowed down by the ordered and dense morphology of gel units;the mass-loss rate of DW-based fiber scaffold on the fifth day is 91.16%while that of IPA-based fiber scaffold is 73.86%;the denser the gel unit,the lower the swelling degree,and the swelling balance has a retarding effect on the degradation process.

关 键 词：海藻酸钠 水凝胶 异丙醇(IPA) 极性 胶束 降解 

分 类 号：TQ427.26[化学工程] R318.08[医药卫生—生物医学工程]