白色念珠菌胞外囊泡的组成及其功能研究进展  

Research progress on the composition and function of extracellular vesicles of Candida albicans

作　　者：韦瑜 程磊[1] 任彪[1] WEI Yu;CHENG Lei;REN Biao(State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Department of Operative Dentistry and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610000,Sichuan,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙体牙髓病科,四川成都610000

出　　处：《微生物学报》2022年第2期434-445,共12页Acta Microbiologica Sinica

基　　金：国家自然科学基金(81870778);四川省科技计划(2020YJ0227)。

摘　　要：念珠菌病指念珠菌属引起的急性、亚急性或慢性感染,通常累及皮肤、黏膜,也可累及内脏和各个系统器官,可造成严重后果,是目前发病率最高的深部真菌病。白色念珠菌是念珠菌种中最为常见的一种机会致病性真菌,近来,越来越多的研究证实了白色念珠菌的细胞外囊泡对其致病性具有重要的作用,它参与重要蛋白、遗传物质的转运,影响白色念珠菌的耐药性,并与宿主细胞进行信息沟通,介导宿主的炎症、免疫反应;还有研究表明胞外囊泡具有免疫活性,可作为一种疫苗制剂使用。因此,本文就白色念珠菌胞外囊泡的组成及其功能总结综述,为未来进一步研究提供参考。Candidiasis refers to the acute,subacute or chronic infection caused by Candida,which usually involves the skin and mucosa,as well as internal organs and various system organs,and can cause serious consequences.It is a deep mycosis with the highest incidence at present.Candida albicans is one of the most common opportunistic pathogenic fungi in Candida species.Recently,more and more studies have confirmed that the extracellular vesicles of Candida albicans play an important role in its pathogenicity.They are involved in the transport of important proteins and genetic materials,influence the drug resistance of Candida albicans,and communicate with host cells to mediate the inflammatory and immune responses of the host.Some studies have shown that extracellular vesicles have immune activity and can be used as a vaccine preparation.Therefore,this paper reviews the composition and function of extracellular vesicles of Candida albicans in order to provide reference for further research in the future.

关 键 词：白色念珠菌 胞外囊泡 蛋白质 脂质 炎症反应 免疫反应 

分 类 号：R379.4[医药卫生—病原生物学]