纳米复合水凝胶在人工软骨中的研究进展  

Research progress of nanocomposite hydrogels in artificial cartilage

作　　者：萧彤 陈怡霏 黄江鸿[2] 孙树清 Tong Xiao;Yifei Chen;Jianghong Huang;Shuqing Sun(Shenzhen International Graduate School,Tsinghua University,Shenzhen 518055,China;Central Laboratory of Shenzhen Second People’s Hospital,Shenzhen 518000,China)

机构地区：[1]清华大学深圳国际研究生院,深圳518055 [2]深圳市第二人民医院中心实验室,深圳518000

出　　处：《中国科学：化学》2022年第2期162-180,共19页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:21874082);深圳市科技创新委员会基础研究学科布局(编号:JCYJ20200109143014453,JCYJ20170817172150505)资助项目。

摘　　要：纳米复合水凝胶(nanocomposite hydrogels,NC hydrogels)作为人工软骨修复材料有很大的应用价值和吸引力.由于NC水凝胶具有与天然软骨细胞外基质(extracellular matrix,ECM)相似的结构,以及较好的力学性能、刺激响应性等优势,是软骨修复的理想支架材料.本综述详细介绍了用于人工软骨的NC水凝胶的最新研究进展,并按其成分加以分类,同时,介绍了其新型制备方法及使用范围,并讨论了NC水凝胶在临床应用的挑战与展望.Nanocomposite hydrogels(NC hydrogels) have great application and attract much attention as artificial cartilage repair materials. It is an ideal scaffold material for cartilage repair due to its structural similarity to natural chondrocyte extracellular matrix(ECM), good mechanical properties and stimulating response. In this review, the latest research progress of NC hydrogels for artificial cartilage is introduced in detail, which is classified by their components.At the same time, the new molding methods and application of NC hydrogel scaffolds are summarized. Besides, the challenges and prospects of the clinical application of NC hydrogels are discussed.

关 键 词：纳米复合水凝胶 组织工程 软骨修复 

分 类 号：TQ427.26[化学工程] R318.08[医药卫生—生物医学工程]