NK细胞的抗肿瘤机制及其在肿瘤靶向治疗中的应用研究进展  

Research advances on antitumor mechanism of NK cells and its application in cancer targeted therapy

作　　者：张淑芬 曾颖萍 孟廷廷 袁弘[1] 胡富强[1] ZHANG Shu-fen;ZENG Ying-ping;MENG Ting-ting;YUAN Hong;HU Fu-qiang(College of Pharmaceutical Science,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]浙江大学药学院,浙江杭州310058

出　　处：《药学学报》2022年第1期122-133,I0005,共13页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81773648,81973267).

摘　　要：自然杀伤(natural killer,NK)细胞是固有免疫的重要组成部分,可通过表面抑制性受体与激活性受体的协同作用活化后,直接识别杀伤肿瘤细胞;可分泌细胞因子募集树突状细胞(dendritic cells,DCs),促进DCs成熟,增强适应性免疫应答;可杀伤肿瘤干细胞(cancer stem cells,CSCs)与循环肿瘤细胞(circulating tumor cells,CTCs),维持肿瘤细胞休眠,抑制肿瘤转移。NK细胞具备独特的炎症趋向性,可响应肿瘤部位释放的细胞因子与趋化因子迁徙至肿瘤部位,使其在抗肿瘤靶向治疗中占据重要优势。因此,NK细胞载体、NK细胞膜包被仿生化载体和NK细胞外囊泡(NK cell extracellular vesicles,NKEVs)的肿瘤靶向治疗研究,受到越来越多的关注。本文将重点介绍NK细胞抗肿瘤作用机制及其在肿瘤靶向治疗中的应用研究进展。Natural killer(NK)cells,as an essential part of innate immunity,can directly identify and kill tumor cells after being activated by the synergistic action of surface inhibitory receptors and activated receptors.It can secrete cytokines to recruit dendritic cells(DCs),induce DCs maturation and enhance adaptive immune response.It can target cancer stem cells(CSCs)and circulating tumor cells(CTCs)to inhibit cancer metastasis.NK cells have a unique inflammatory tendency,which can respond to cytokines and chemokines released from tumor sites and migrate to tumor sites,making them occupy an important advantage in cancer targeted therapy.The research on cancer targeted therapy of NK cells as drug delivery carriers,NK cell membrane-coated biomimetic nanoparticles,and NK cell extracellular vesicles(NKEVs)has attracted more and more attention.The article will focus on the mechanism of NK cells inhibiting cancer,and summarize the research progress of cancer targeted therapy of NK cells.

关 键 词：自然杀伤细胞 肿瘤免疫治疗 肿瘤靶向 仿生纳米粒 药物递送 

分 类 号：R943[医药卫生—药剂学]