北京市婴儿早期维生素D营养状况与体格生长发育的关系  

Early vitamin D nutritional status and its relationship with physical growth in infants in Beijing

作　　者：李一辰[1] 尚晓瑞[1] 何辉[1] LI Yichen;SHANG Xiaorui;HE hui(Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Maternal and Child Health Care Hospital,Beijing 100026.China)

机构地区：[1]首都医科大学附属北京妇产医院/北京妇幼保健院,北京100026

出　　处：《中国妇幼健康研究》2021年第12期1723-1728,共6页Chinese Journal of Woman and Child Health Research

基　　金：国家重点研发计划(2016YFC1000304)。

摘　　要：目的评估北京地区婴儿早期维生素D营养状况,探讨其与体格生长发育的关系。方法选取2020年4至10月在北京妇产医院门诊进行42天常规体检、年龄在36~48天的1160例健康婴儿作为研究对象,对其进行身长、体重等体格测量和血清25-羟基维生素D[25(OH)D]水平的测定。根据维生素D营养状况将所有婴儿分为缺乏组、不足组和正常组,分析3组婴儿身长、体重和体质量指数(BMI)等的差异。结果1160例婴儿血清25(OH)D的平均水平为(25.33±6.82)ng/mL,其中男婴为(25.46±6.70)ng/mL,女婴为(25.21±6.94)ng/mL。维生素D缺乏率、不足率和正常率分别为22.24%、55.09%和22.67%,维生素D水平和营养状态性别间差异均无统计学意义(P>0.05)。缺乏组、不足组和正常组42天体检时的体重、BMI和BMI增量差异均有统计学意义(F值分别为4.397、8.788、4.042,P<0.05);体重增量、身长和身长增量在3组间的差异均无统计学意义(P>0.05)。两两比较显示,缺乏组的婴儿42天体检时体重高于正常组,BMI和BMI增量均高于不足组和正常组(P<0.05)。分层分析显示,42天体检时男婴中维生素D缺乏组仅BMI高于正常组(P<0.05);女婴中维生素D缺乏组其体重、BMI和BMI增量均高于不足组和正常组(P<0.05)。不同BMI的婴儿其25(OH)D水平差异有统计学意义(F=3.979,P<0.05),肥胖婴儿的25(OH)D水平低于BMI正常者(P<0.05),且肥胖婴儿的维生素D缺乏率高于BMI正常者(χ^(2)=8.287,P<0.05)。结论北京地区婴儿早期维生素D缺乏或不足率较高,婴儿早期维生素D缺乏与肥胖有一定相关性。Objective To evaluate the early vitamin D(VitD)nutritional status of infants in Beijing,and explore its relationship with physical growth.Methods 1160 healthy infants aged 36-48 days who went to Beijing Obstetrics and Gynecology Hospital for 42-day physical examination from April 2020 to October 2020 were included in this study.The body length,weight and serum 25-hydroxy vitamin D[25(OH)D]concentration were measured.VitD status was defined as deficiency,insufficiency,and normal.The differences in the length,weight and body mass index(BMI)of the three groups of infants were analyzed.Results The average level of serum 25(OH)D was(25.33±6.82)ng/mL,with(25.46±6.70)ng/mL in boys and(25.21±6.94)ng/mL in girls.VitD deficient rate,insufficient rate and normal rate were 22.24%,55.09% and 22.67%,respectively.And there were no significant differences in gender(P>0.05).The differences in body weight,BMI and BMI increment in the 42-day physical examination of the deficiency group,the insufficiency group and the normal group were statistically significant(F=4.397,8.788,and 4.042,respectively,P<0.05).There was no significant difference in weight gain,body length and body length gain among the three groups(P>0.05).Pairwise comparison showed that the infants in the deficiency group had higher body weight than the normal group at 42-day physical examination,and the increment in BMI and BMI were higher than those in the deficiency group and the normal group(P<0.05).Stratified analysis showed that only boys with vitamin D deficiency at 42-day physical examination had higher BMI than the normal group(P<0.05).Girls with vitamin D deficiency had higher body weight,BMI and BMI increment than those of the insufficient group and the normal group(P<0.05).The 25(OH)D levels of infants with different BMI were statistically different(F=3.979,P<0.05).The 25(OH)D level of obese infants was lower than that of the normal BMI group(P<0.05).And the vitamin D deficient rate in the obese group was higher than that in the normal BMI group(χ^(2)=8.

关 键 词：维生素D 婴儿 体格生长发育 BMI 肥胖 

分 类 号：R174[医药卫生—妇幼卫生保健]