氟比洛芬酯对脊柱结核术后发热的影响分析  

Analysis of the Effect of Flurbiprofen Axetil on Postoperative Fever in Patients with Spinal Tuberculosis

作　　者：曹晓曼 刘伟[1] 刘涛[1] 王春[1] 高广阔[1] 翟文廷 陈玢[1] 吴春雨 Cao Xiaoman;Liu Wei;Liu Tao;Wang Chun;Gao Guangkuo;Zhai Wenting;Chen Bin;Wu Chunyu

机构地区：[1]北京市结核病胸部肿瘤研究所,首都医科大学附属北京胸科医院麻醉科,101149

出　　处：《结核病与胸部肿瘤》2021年第3期201-204,共4页Tuberculosis and Thoracic Tumor

摘　　要：为分析术后镇痛应用氟比洛芬酯对脊柱结核术后发热的影响,笔者采用回顾性分析方法,收集2017年1月至2019年1月于首都医科大学附属北京胸科医院行脊柱结核手术的255例患者的临床资料(包括手术时间、切口数量、手术部位、是否术中输血、是否术中应用糖皮质激素、是否术后镇痛应用氟比洛芬酯,以及术后2d发热情况等)进行分析。结果显示,研究对象术后第1天发热率为44.7%(114/255),应用氟比洛芬酯镇痛者中未发热者占77.3%(109/141),明显高于未应用氟比洛芬酯镇痛者[22.7%(32/141)],差异有统计学意义(χ^(2)=11.970,P=0.001)。研究对象术后第2天发热率为28.6%(73/255),应用氟比洛芬酯镇痛者中未发热者占72.5%(132/182),明显高于未应用氟比洛芬酯镇痛者[27.5%(50/182)],差异有统计学意义(χ^(2)=5.400,P=0.020)。多因素logistic回归分析显示,脊柱结核术后第1天及第2天,应用氟比洛芬酯镇痛者发热风险降低[OR(95%CI)值分别为0.319(0.178〜0.570)和0.412(0.222〜0.764)]。根据结果可知,术后镇痛应用氟比洛芬酯可降低脊柱结核患者术后发热风险。This is a retrospective study to analyze the effect of postoperative analgesia with flurbiprofen axetil on postoperative fever in spinal tuberculosis patients.The clinical data(operation time,number of incisions,operation site,intraoperative blood transfusion,intraoperative use of glucocorticoid,the use of flurbiprofen axetil as postoperative analgesia,and fever 2 days after operation)of 255 spinal tuberculosis patients undergoing surgery in Beijing Chest Hospital from January 2017 to January 2019 were analyzed.The results showed that the fever rate was 44.7%(114/255)on the first day after operation,and 77.3%(109/141)of the patients who used flurbiprofen axetil for analgesia had no fever,which was significantly higher than that of the patients who did not use flurbiprofen axetil for analgesia(22.7%(32/141),χ^(2)=11.970,P=0.001).The fever rate was 28.6%(73/255)on the second day after operation,and 72.5%(132/182)of the patients who used flurbiprofen axetil for analgesia had no fever,which was significantly higher than that of the patients who did not use flurbiprofen axetil for analgesia(27.5%(50/182),χ^(2)=5.400,P=0.020).Multivariate logistic analysis showed that on the first and second day after spinal tuberculosis surgery,the risk of fever was reduced values(OR(95%CI)were 0.319(0.178-0.570)and 0.412(0.222-0.764),respectively).According to the results,postoperative analgesia with flurbiprofen axetil could reduce the risk of postoperative fever in patients with spinal tuberculosis.

关 键 词：结核 脊柱 外科手术 消炎药 非甾类 发热 

分 类 号：R47[医药卫生—护理学]