四种抗菌药物治疗老年患者社区获得性下尿路感染的成本-效果分析  

Cost-effect Analysis of Four Antimicrobial Drugs to Treat Urinary Tract Infections in the Elderly Community

作　　者：杨提 陆燕 陈丽文 刘艳辉[1] 姚佳晨[1] 李文艳[1] YANG Ti;LU Yan;CHEN Li-wen;LIU Yan-hui;YAO Jia-chen;LI Wen-yan(Department of Pharmacy,Shanghai Pudong New Area Gongli Hospital,Shanghai 200135,China)

机构地区：[1]上海市浦东新区公利医院药剂科,上海200135

出　　处：《医学信息》2022年第2期157-159,共3页Journal of Medical Information

基　　金：上海市浦东新区卫生和计划生育委员会临床药学重点学科资助项目(编号:PWZxk2017-13)。

摘　　要：目的应用药物经济学原理对四种抗菌药物治疗老年尿路感染的成本-效果比进行分析,从中找出最佳的药物治疗方案。方法选取2018年7月-2019年9月我院门诊确诊的老年尿路感染患者320例,根据抗菌药物治疗方案分为A组、B组、C组及D组,每组80例。A组口服头孢克肟分散片,B组口服磷霉素氨丁三醇散,C组口服盐酸左氧氟沙星分散片,D组口服左氧氟沙星片,比较各组临床疗效及不良反应,根据各组患者的药物治疗效果进行成本-效果及敏感度分析。结果A组、B组、C组及D组的总有效率分别为76.25%、72.50%、61.25%和73.75%,四组间比较,差异无统计学意义(P>0.05);四组患者不良反应轻且均在可耐受范围内;A组、B组、C组及D组的成本-效果比分别为1.89、2.80、0.52和1.04,C组最低,D组次之;敏感度分析显示,C组<D组<A组<B组。结论从药物经济学角度分析,考虑药物治疗成本与疗效后,左氧氟沙星片的成本-效果比最低,为最佳给药方案。Objective To analyze the cost-effect ratio of four antimicrobial drugs in the treatment of urinary tract infection in the elderly by using the principle of pharmacoeconomics,and to find out the best drug treatment scheme.Methods A total of 320 elderly patients with urinary tract infection diagnosed in our hospital from July 2018 to September 2019 were selected and divided into group A,group B,group C and group D according to the antibiotic treatment plan,with 80 cases in each group.Group A was treated with cefixime dispersible tablets,group B was treated with fosfomycin aminobutanol powder,group C was treated with levofloxacin hydrochloride dispersible tablets,and group D was treated with levofloxacin tablets.The clinical efficacy and adverse reactions of each group were compared.Cost-effect and sensitivity analysis were carried out according to the drug treatment effect of each group.Results The total effective rates of group A,group B,group C and group D were 76.25%,72.50%,61.25%and73.75%,respectively;There was no significant difference between the four groups(P>0.05).The adverse reactions of the four groups were mild and tolerable;the cost-effect ratios of group A,group B,group C and group D were 1.89,2.80,0.52 and 1.04,respectively,which were the lowest in group C and the second in group D.Sensitivity analysis showed that group C<group D<group A<group B.Conclusion From the perspective of pharmacoeconomics,the cost-effectiveness ratio of levofloxacin tablets is the lowest after considering the cost and efficacy of drug treatment,which is the best drug administration scheme.

关 键 词：抗菌药物 成本-效果 敏感度 药物经济学 

分 类 号：R378[医药卫生—病原生物学]