肾结石与血脂浓度的相关性  

Correlation between kidney stones and blood lipid concentration

作　　者：李博[1] 周亮[1] 金熙[1] 李虹[1] 黄燕[2] 王坤杰[1] LI Bo;ZHOU Liang;JIN Xi;LI Hong;HUANG Yan;WANG Kunjie(Department of Urology,Institute of Urology,Laboratory of Reconstructive Urology,Sichuan University,Chengdu 610000,China;Health Management Center,West China Hospital,Sichuan University,Chengdu 610000,China)

机构地区：[1]四川大学华西医院泌尿外科/泌尿外科研究所泌尿系修复与重建研究室,四川成都610000 [2]四川大学华西医院健康管理中心,四川成都610000

出　　处：《现代泌尿外科杂志》2022年第1期35-38,74,共5页Journal of Modern Urology

摘　　要：目的探究人群中血脂浓度与肾结石的相关性。方法回顾性收集2018年1月-2019年1月于四川省华西医院体检中心进行健康体检人群的一般资料和临床资料。所有体检人群抽取空腹血检查血清血脂情况,泌尿系统彩超诊断肾结石、泌尿系腹部平片(KUB)和全腹部计算机断层扫描(CT)作为重要补充。结果共纳入18644人,其中结石组385(2.1%)例、非结石组18259(97.9%)例。结石组中高甘油三酯(TG)血症人群所占比例(19.5%)明显高于非结石组(14.6%),差异有统计学意义(P<0.05)。结石组比非结石组的低密度脂蛋白胆固醇(LDL-C)水平高者(8.8%vs.7.8%)、高总胆固醇(TC)血症者(9.4%vs.8.9%)、高密度脂蛋白胆固醇(HDL-C)水平低者(10.9%vs.8.9%)占比高,但差异无统计学意义(P>0.05)。二元logsitic多因素分析调整年龄、性别、体质指数(BMI)、糖尿病、高血压、血肌酐、血尿素、尿pH等指标后发现,血清TG浓度升高是肾结石发生的危险因素,血TG浓度升高比血TG浓度正常的患者患肾结石的风险高1.16倍。结论肾结石患者血脂异常的比例更高,高TG血症可能是肾结石发生的危险因素,血TG浓度升高比血TG浓度正常的患者患肾结石的风险更高。因此在预防肾结石发生时,要更加关注血脂异常的治疗,特别是血TG异常的治疗。Objective To investigate the relationship between blood lipid concentration and kidney stones.Methods The general and clinical data of people who underwent physical examination at the West China Hospital of Sichuan University during Jan.2018 and Jan.2019 were collected.The lipid profile was examined with fasting blood.Kidney stones were diagnosed with kidney ureter bladder(KUB),and abdominal computed tomography(CT).Results A total of 18644 patients were enrolled,including 385 with stones and 18259 without stones.The proportion of patients with high triglyceride(TG)was higher in the stone group than in the non-stone group(19.5%vs 14.6%,P<0.05).The proportion of patients with high low-density lipoprotein cholesterol(LDL-C)was higher in the stone group than in the non-stone group(8.8%vs 7.8%).The proportion of patients with high total cholesterol(TC)was higher in the stone group than in the non-stone group(9.4%vs 8.9%).The proportion of patients with high-density lipoprotein cholesterol(HDL-C)was higher in the stone group than in the non-stone group(10.9%vs 8.9%,P>0.05).After age,gender,BMI,diabetes,hypertension,serum creatinine,blood urea and urine pH were adjusted,binary logsitic multivariate analysis showed that increased blood TG concentration was a risk factor for the occurrence of kidney stones,and the risk of patients with increased blood TG concertation was 1.16 times higher than that of patients with normal blood TG concentration.Conclusion Patients with kidney stones have a higher rate of dyslipidemia,which may be a risk factor for the occurrence of kidney stones.Patients with elevated blood TG concentration have a higher risk of kidney stones than those with normal blood TG concentration.Therefore,in the prevention of kidney stones,due attention should be paid to the treatment of dyslipidemia,especially abnormal blood TG.

关 键 词：肾结石 泌尿系结石 血脂异常 高甘油三酯血症 

分 类 号：R692[医药卫生—泌尿科学]