微管蛋白在巨核细胞发育和血小板数量调控中的作用机制研究进展  

Research Progress on the Mechanism of Tubulin in Megakaryopoiesis and Regulation of Platelet Count——Review

作　　者：牛思颖 夏利军[1,2] 江淼 NIU Si-Ying;XIA Li-Jun;JIANG Miao(National Clinical Medical Research Center of Blood Diseases,Jiangsu Institute of Hematology,The First Affiliated Hospital of Soochow University,Suzhou 215007,China;Key Laboratory of Thrombosis&Hemostasis of National Health Commission of People's Republic of China,Suzhou 215006,China)

机构地区：[1]苏州大学附属第一医院,江苏省血液研究所,国家血液系统疾病临床医学研究中心,江苏苏州215007 [2]国家卫生健康委员会血栓与止血重点实验室,江苏苏州215006

出　　处：《中国实验血液学杂志》2022年第1期323-326,共4页Journal of Experimental Hematology

摘　　要：微管蛋白在巨核祖细胞向血小板发育成熟的过程中通过对有丝分裂的控制和原血小板的形成影响血小板的数量。在血小板中微管蛋白参与维持血小板骨架的完整,并在血小板活化过程中参与血小板形态的改变。一些以细胞有丝分裂为靶向的抗肿瘤新药正试图有针对性地减少对微管蛋白的影响以减轻药物对血小板生成的抑制作用。临床上一些血小板减少症患者由于微管蛋白基因的变异和多态性影响了微管多聚体的结构从而导致血小板生成减少。本文对微管蛋白在巨核细胞发育成熟和血小板生成调控过程中的最新研究进展作一综述。Objective: Tubulin affects platelets count through the control of mitosis and the formation of pro-platelets during the maturation of megakaryoblast to platelets. Tubulin is involved in maintaining the integrity of platelet skeleton, and also participates in the change of platelet morphology during platelet activation. Some new anti-tumor drugs targeting cell mitosis are trying to reduce the effect on tubulin in order to reduce the side effect of drugs on platelet formation. In some patients with thrombocytopenia, the variation and polymorphism of the tubulin gene affect the structure of microtubule multimers, which leads to the decrease of platelet formation. This review summarized the latest progresses of tubulin in the regulation of megakaryopoiesis and thrombopoiesis.

关 键 词：微管蛋白 TUBB1 巨核细胞 血小板生成 血小板减少 

分 类 号：R331.143[医药卫生—人体生理学]