老年2型糖尿病患者中非酒精性脂肪性肝病与代谢性指标的相关性  

Correlation between nonalcoholic fatty liver disease and metabolic markers in elderly patients with type 2 diabetes mellitus

作　　者：李小林 何伟[2] 刘盛扶 LI Xiao-lin;HE Wei;LIU Sheng-fu(The Second Hospital of Huangshi City,Huangshi,Hubei 435000,China;Central Hospital of Huangshi City,Huangshi,Hubei 435000,China)

机构地区：[1]黄石市第二医院,湖北黄石435000 [2]黄石市中心医院,湖北黄石435000

出　　处：《实用预防医学》2022年第2期145-148,共4页Practical Preventive Medicine

摘　　要：目的了解老年2型糖尿病(type 2 diabetes mellitus,T2DM)合并非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)与代谢性指标的相关性,为NAFLD的治疗及预防提供依据。方法选取2018年12月1日―2019年12月31日黄石市第二医院就诊的T2DM患者为调查对象。根据T2DM患者是否合并NAFLD分为NAFLD组和对照组。调查患者的基本情况并进行体格检查,检测生化指标。采用多因素logistic回归分析T2DM是否合并NAFLD的影响因素。结果共纳入279例调查对象,非NAFLD组177人,占63.44%;平均年龄(70.06±6.75)岁;病程≤5年70人,占39.55%;>5年107人,占60.45%。NAFLD组102人,占36.56%;平均年龄(70.19±5.81)岁;病程≤5年37人,占36.27%;>5年65人,占63.73%。多因素logistic回归分析结果显示,空腹血糖升高(OR=5.361,95%CI:1.811~15.867)、高血压(OR=1.843,95%CI:1.091~3.114)和总胆固醇升高(OR=2.637,95%CI:1.565~4.444)是T2DM合并NAFLD的危险因素。结论空腹血糖升高、高血压和总胆回醇升高与T2DM合并NAFLD有关。Objective To investigate the relationship between elderly type 2 diabetes mellitus(T2DM)combined with nonalcoholic fatty liver disease(NAFLD)and metabolic markers,and to provide evidence for NAFLD treatment and prevention.Methods T2DM patients who visited the Second Hospital of Huangshi City from December 1,2018 to December 31,2019 were selected as the surveyed subjects.According to whether T2DM patients suffered from NAFLD or not,they were divided into the NAFLD group and the control group.General information about the patients was investigated,physical examination was conducted,and biochemical indexes were measured.Multivariate logistic regression analysis was performed to identify the factors influencing T2DM with or without NAFLD.Results A total of 279 surveyed subjects were enrolled in the study,and the non-NAFLD group included 177(63.44%)patients,with the mean age of(70.06±6.75)years.There were 70(39.55%)patients with the course of the disease less than or equal to 5 years and 107(60.45%)patients with the course of the disease more than 5 years.The NAFLD group included 102(36.56%)patients,with the mean age of(70.19±5.81)years.There were 37(36.27%)patients with the course of the disease less than or equal to 5 years and 65(63.73%)patients with the course of the disease more than 5 years.Multivariate logistic regression analysis displayed that the increase of fasting plasma glucose(FPG)(OR=5.361,95%CI:1.811-15.867),hypertension(OR=1.843,95%CI:1.091-3.114)and elevated total cholesterol(OR=2.637,95%CI:1.565-4.444)were the risk factors of T2DM combined with NAFLD.Conclusion Increased FPG,hypertension and elevated TC are associated with T2DM complicated by NAFLD.

关 键 词：2型糖尿病 非酒精性脂肪性肝病 代谢因素 危险因素 

分 类 号：R587.1[医药卫生—内分泌]