外周血造血干细胞动员采集对供者凝血功能影响的研究  

Blood coagulation function before and after peripheral blood stem cell mobilization and collection

作　　者：田丹[1] 王刚 何苏英 李少文[1] 郭楚霞 彭永正[1] 陆志刚[1] TIAN Dan;WANG Gang;HE Suying;LI Shaowen;GUO Chuxia;PENG Yongzheng;LU Zhigang(Department of Blood Transfusion,Zhu-jiang Hospital,Southern Medical University,Guangzhou 510280,China)

机构地区：[1]南方医科大学珠江医院输血科,广东广州510280

出　　处：《中国输血杂志》2022年第1期32-34,共3页Chinese Journal of Blood Transfusion

摘　　要：目的探讨外周血造血干细胞(PBSC)动员和采集前后供者凝血功能变化并评估现行采集方案的安全性。方法纳入2018年10月~2020年10月在本院行PBSC动员和采集的供者30名,经粒细胞集落刺激因子(G-CSF)动员,于PBSC单采集前后行血栓弹力图(TEG)与血常规检查;分析供者凝血功能、血常规指标与TEG指标之间的相关性,评估PBSC动员采集对供者凝血功能的影响。结果30名PBSC供者单采集前后TEG指标R(min)、K(min)、α(°)、MA(mm)及CI值分别为6.12±1.18、1.98±0.41、62.82±4.98、60.93±3.26、-0.31±1.40vs 7.25±2.16、2.45±0.64、57.3±6.67、55.37±4.41、-2.32±2.18(P<0.05),提示供者在PBSC动员及采集后均未出现高凝风险;采集后供者的白细胞(×10^(9)/L)、血小板(×10^(9)/L)、血红蛋白(g/L)峰值分别为62.02、357和162,提示供者动员采集后的血常规指标在安全值区间。PBSC采集后26.7%(8/30)供者的CI<-3,提示少数供者出现低凝风险。结论PBSC动员采集后对供者凝血功能的影响较小,绝大多数供者无高凝血风险,但有少数供者凝血功能出现低凝倾向。Objective To study the changes of blood coagulation function of donors before and after peripheral blood stem cell(PBSC)mobilization and collection,so as to evaluate the safety of the current scheme.Methods 30 donors who received PBSC mobilization and collection in Zhujiang Hospital from October 2018 to October 2020 were enrolled.After mobilization by G-CSF,the correlation between coagulation function,blood routine indexes and TEG indexes of donors was analyzed,and the influence of PBSC mobilization and collection on coagulation function of donors was evaluated.Results The TEG indexes R(min),K(min),α(°),MA(mm)and CI before and after PBSC collection were 6.12±1.18 vs 7.25±2.16,1.98±0.41 vs 2.45±0.64,62.82±4.98 vs 57.3±6.67,60.93±3.26 vs 55.37±4.41,and-0.31±1.40 vs-2.32±2.18,respectively(P<0.05),suggesting that there was no risk of hypercoagulability after PBSC mobilization and collection.The peak values of WBC(×10^(9)/L),Plt(×10^(9)/L)and Hb(g/L)were 62.02,357 and 162,respectively,which indicated that the blood routine indexes after PBSC mobilization and collection were in the safe range.After PBSC collection,the CI value of 26.7%(8/30)donors was less than-3,showing hypocoagulability.Conclusion The current mobilization and collection scheme of PBSC has little effect on the coagulation function.Most of the donors had no risk of hypercoagulability,but a few showed a trend of hypocoagulability after PBSC collection.

关 键 词：外周血干细胞供者 外周血干细胞动员/采集 凝血功能 血常规 

分 类 号：R457.1[医药卫生—治疗学] R446.11[医药卫生—临床医学]