孕期血尿酸水平对儿童先天性心脏病的影响  

Effect of Serum Uric Acid Level During Pregnancy on Congenital Heart Disease in Children

作　　者：陈丽[1] 宋艳琴 CHEN Li;SONG Yan-qin(Department of Obstetrics,Baoji Maternal and Child Health Hospital,Baoji 721000)

机构地区：[1]宝鸡市妇幼保健院产科,陕西宝鸡721000 [2]铜川市耀州区人民医院妇产科,陕西铜川727100

出　　处：《医学临床研究》2022年第1期52-54,共3页Journal of Clinical Research

摘　　要：【目的】探讨孕期血尿酸水平对儿童先天性心脏病(CHD)的影响。【方法】在本院产科分娩了CHD儿童的孕妇20例作为观察组,选取同时期后代未患有CHD的孕妇100例作为对照组。比较两组血尿酸水平及相关指标,采用二分类Logistic回归分析孕妇各项指标与后代CHD的关系。【结果】两组孕妇平均年龄、孕周、产次、体重指数(BMI)等相比较差异无统计学意义(P>0.05)。观察组孕妇血尿酸水平、二手烟暴露率、流产史、高尿酸血症患病率均显著高于对照组,且两组之间比较差异均有统计学意义(P<0.05)。单因素Logistic回归分析结果显示,母亲BMI、二手烟暴露、流产史及高尿酸血症与后代CHD的发病风险呈相关性(P<0.05),而与年龄、孕周、孕次、产次无相关性(P>0.05)。将单因素分析有意义的指标纳入多因素logistic回归分析,采用逐步进入的方法,结果显示:母亲BMI、二手烟暴露、流产史及高尿酸血症是后代CHD的独立危险因素(P<0.05)。【结论】孕期血尿酸水平升高是儿童CHD的危险因素,积极治疗孕妇高尿酸血症可能会降低儿童CHD的发病率。【Objective】To investigate the effect of serum uric acid level during pregnancy on children with congenital heart disease(CHD).【Methods】A total of 20 pregnant women who gave birth to CHD children in the obstetrics of our hospital were selected as the observation group,and 100 pregnant women whose offspring did not suffer from CHD in the same period were selected as the control group.The levels of serum uric acid and related indexes were compared between the two groups.The relationship between maternal indexes and offspring CHD was analyzed by binary logistic regression.【Results】There was no significant difference in average age,gestational weeks,times of delivery and body mass index(BMI)between the two groups(P>0.05).The serum uric acid level,second-hand smoke exposure rate,abortion history and prevalence of hyperuricemia in the observation group were significantly higher than those in the control group,and there were significant differences between the two groups(P<0.05).Univariate logistic regression analysis showed that maternal BMI,second-hand smoke exposure,abortion history and hyperuricemia were correlated with the risk of CHD in offspring(P<0.05),but not with age,gestational week,gestational times and delivery times(P>0.05).The significant indexes of univariate analysis were included in multivariate logistic regression analysis.The results showed that maternal BMI,second-hand smoke exposure,abortion history and hyperuricemia were independent risk factors for CHD in offspring(P<0.05).【Conclusion】Elevated serum uric acid level is a risk factor for CHD in children.Active treatment of hyperuricemia in pregnant women may reduce the incidence rate of CHD in children.

关 键 词：心脏缺损 先天性 儿童 妊娠 尿酸/血液 

分 类 号：R725.411[医药卫生—儿科]