线粒体自噬相关受体蛋白研究进展  

Advances in the study of mitophagy-related receptor proteins

作　　者：马穰桂 夏志 尚画雨[1] MA Rang-Gui;XIA Zhi;SHANG Hua-Yu(School of Sports Medicine and Health,Chengdu Sport University,Chengdu 610041,China;College of Physical Education and Health,Wenzhou University,Wenzhou 325035,China;Physical Education College of Jinggangshan University,Ji'an 343009,China)

机构地区：[1]成都体育学院运动医学与健康学院,成都610041 [2]温州大学体育与健康学院,温州325035 [3]井冈山大学体育学院,吉安343009

出　　处：《生理学报》2021年第6期1025-1034,共10页Acta Physiologica Sinica

基　　金：supported by the National Natural Science Foundation of China(No.31900842,31960192);the Innovative Project of Institute of Sports Medicine and Health of Chengdu Sport University(No.CX21A01);the Jiangxi Provincial Science Fund for Distinguished Young Scholars(No.20202ACBL216004);the Jiangxi Provincial Natural Science Foundation(No.20192BAB205081)。

摘　　要：细胞通过自噬方式选择性清除多余或损伤的线粒体,是细胞内线粒体质量控制的重要机制。近期研究表明,酵母细胞主要通过自噬相关基因(Atgs)调控线粒体自噬,而哺乳动物细胞内则由PTEN诱导激酶1(PTEN-induced putative kinase 1,PINK1)、NIX/BNIP3L、BNIP3、FUNDC1(FUN14 domain containing 1)、FKBP8/FKBP38、Bcl-2样蛋白13(Bcl-2-like protein 13,Bcl2L13)、含核苷酸结合结构域和富亮氨酸重复序列的蛋白家族成员X1(NLRX1)、抗增殖蛋白(PHB2)等线粒体膜相关蛋白和心磷脂(cardiolipin,CL)等脂类作为介导线粒体自噬的关键受体而选择性识别受损的线粒体,并通过与微管相关蛋白1轻链3(microtubule-associated protein 1 light chain 3,LC3)或γ-氨基丁酸受体相关蛋白(γ-aminobutyric acid receptor-associated protein,GABARAP)结合将其包裹在自噬体内,最终被溶酶体降解清除。本文对线粒体自噬相关受体蛋白的近期研究进展进行综述。Cells selectively scavenge redundant or damaged mitochondria by mitophagy,which is an important mechanism of mitochondrial quality control.Recent studies have shown that mitophagy is mainly regulated by autophagy-related genes(Atgs)in yeast cells,while mitochondrial membrane associated proteins such as PTEN-induced putative kinase 1(PINK1),NIX/BNIP3 L,BNIP3,FUN14 domain containing 1(FUNDC1),FKBP8/FKBP38,Bcl-2-like protein 13(Bcl2 L13),nucleotide binding domain and leucine-rich-repeat-containing proteins X1(NLRX1),prohibitin 2(PHB2)and lipids such as cardiolipin(CL)are the key mitophagic receptors in mammalian cells,which can selectively recognize damaged mitochondria,recruit them into isolation membranes by binding to microtubule-associated protein 1 light chain 3(LC3)orγ-aminobutyric acid receptor-associated protein(GABARAP),and then fuse with lysosomes to eliminate the trapped mitochondria.This article reviews recent research progress of mitophagy-related receptor proteins.

关 键 词：线粒体 细胞自噬 线粒体自噬 受体 

分 类 号：R3[医药卫生—基础医学] Q4[生物学—生理学]