运动改善胰岛β细胞功能障碍的研究进展  

Research Progress of Exercise Improving Dysfunction of IsletβCells

作　　者：杨坡 张跃耀 阿力木•热合曼 何恩鹏[1] YANG Po;ZHANG Yueyao;REHEMAN·Alimu;HE Enpeng(Key Laboratory of Human Exercise Science College of Life Sciences,School of Physical Education Xinjiang Normal University,Urumqi 830054,China)

机构地区：[1]新疆师范大学体育学院,运动人体科学重点实验室,乌鲁木齐830054

出　　处：《中国细胞生物学学报》2021年第12期2402-2408,共7页Chinese Journal of Cell Biology

基　　金：新疆维吾尔自治区自然科学基金项目(批准号:2021D01A120);新疆维吾尔自治区高校科研计划项目(批准号:XJEDU2020Y032);自治区研究生科研创新项目(批准号:XJ2021G246);新疆维吾尔自治区体育人文社会学重点学科经费资助的课题。

摘　　要：2型糖尿病(type 2 diabetes mellitus,T2DM)是一种复杂的疾病,其引起的并发症(如慢性高血糖、多系统器官功能衰竭和糖尿病神经病变等)会降低患者生活质量,甚至导致患者过早死亡,亦会造成巨大的医疗和社会负担。目前尚未发现能够有效阻止或逆转糖尿病后期并发症发展的治疗方法。既往研究表明,运动疗法一直都是改善T2DM胰岛β细胞功能障碍的有效手段,并且是药物不可替代的治疗方法。该文对运动改善T2DM胰岛β细胞功能的作用进行分析,并对其作用机制进行综述。T2DM(type 2 diabetes mellitus)is a complex disease,and its complications(such as chronic hyperglycemia,systemic metabolic failure and multiple organ damage,etc.)can reduce patients’quality of life,even lead to premature death,and also cause huge medical and social burdens.At present,there are still no therapeutic methods that can effectively prevent or reverse the development of late complications of diabetes.Previous studies have shown that exercise therapy has always been an effective means to improve the isletβcell dysfunction in T2DM,and it is an irreplaceable treatment method for drugs.This paper analyzes the effect of exercise on improving the function of pancreaticβcells in T2DM and reviews the mechanism.

关 键 词：2型糖尿病 运动 胰岛Β细胞 慢性病 

分 类 号：R587.1[医药卫生—内分泌]