射干止咳胶囊抗炎作用初探  

Preliminary Study on Anti-inflammatory Effect of Shegan Zhike Capsule

作　　者：包玉龙[1] 甘雨[1] 范英兰[1] 朱竟赫 武晓琳[1] 刘禾[1] 吴怡[1] 李国信[1] BAO Yulong;GAN Yu;FAN Yinglan;ZHU Jinghe;WU Xiaolin;LIU He;WU Yi;LI Guoxin(Academe of Traditional Chinese Medicine of Liaoning Province,Shenyang 110034,China)

机构地区：[1]辽宁省中医药研究院,沈阳110034

出　　处：《实验动物科学》2021年第6期16-19,共4页Laboratory Animal Science

基　　金：国家“十三五”重大新药创制项目:基于组分中药创新模式的射干新药开发研究,课题编号:2017ZX09301019;辽宁省科技厅课题,组分中药抗呼吸道感染的关键技术研究,课题编号:2020JH2/10300090。

摘　　要：目的探讨射干(Belamcanda chinense)止咳胶囊抗炎作用及相关机制。方法采用小鼠耳肿胀实验和大鼠肉芽肿实验,观察射干止咳胶囊的抗炎作用,并通过检测经脂多糖(LPS)诱导的肺损伤小鼠血清中白介素6(IL-6)及肿瘤坏死因子α(TNF-α)水平,推测其可能的抗炎作用机制。结果与空白对照组比较,射干止咳胶囊低、中、高剂量组均能明显降低小鼠耳肿胀度程度,差异有显著意义(P<0.01~0.05);与模型对照组相比,射干止咳胶囊低、中、高剂量组能够明显降低大鼠肉芽肿的质量,差异有统计学意义(P<0.01~0.05);与模型对照组比较,射干止咳胶囊低、中、高剂量组能够明显降低小鼠血清IL-6和TNF-α水平,差异有统计学意义(P<0.01~0.05)。结论射干止咳胶囊具有一定的抗炎作用,其作用机制可能与抑制炎症因子合成及释放有关。Objective To explore the anti-inflammatory effect and mechanism of Shegan Zhike capsule. Method The anti-inflammatory effect of Shegan Zhike capsule was observed by ear swelling test in mice and granuloma test in rats. The mechanism of anti-inflammatory action was speculated by detecting the levels of interleukin 6( IL-6)and tumor necrosis factor α( TNF-α) in the serum of mice with lung injury induced by lipopolysaccharide( LPS).Result Compared with the blank control group,the low,medium and high doses of Shegan Zhike capsules could significantly reduce the degree of ear swelling in mice,and the difference was significant( P<0. 01 and P<0. 05).Compared with the model control group,the low,medium and high doses of Shegan Zhike capsules could significantly reduce the weight of rat granulomas,and the difference was significant( P < 0. 01 and P < 0. 05).Compared with the model control group,the low,medium and high doses of Shegan Zhike Capsules could significantly reduce the levels of serum IL-6 and TNF-α in mice, and the difference was significant( P<0. 01 and P<0. 05). Conclusion Shegan Zhike capsule has certain anti-inflammatory effect and inhibiting inflammatory factors.

关 键 词：射干止咳胶囊 抗炎作用 炎症因子 

分 类 号：Q95-33[生物学—动物学]