妊娠SD大鼠血糖指标值的系统评价和单组连续变量Meta分析  

Normal Reference Ranges of Blood Glucose Indexes among Pregnant SD Rats:A Systematic Review and Meta-analysis in Single Group Continuous Variables

作　　者：江心泳 葛莉[1] 赖玉婷 黄萍萍 陈凡 庞书勤[1] 于红虹[1] JIANG Xinyong;GE Li;LAI Yuting;HUANG Pingping;CHEN Fan;PANG Shuqin;YU Honghong(Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China)

机构地区：[1]福建中医药大学护理学院,福州350122

出　　处：《实验动物科学》2021年第6期37-46,58,共11页Laboratory Animal Science

基　　金：福建省卫生厅青年科研基金(No.2019-ZQN-75);2019年福建中医药大学重点学科专项校管课题(No.X2019041-学科);2020年国家级大学生创新创业项目(No.202010393011)。

摘　　要：目的确定妊娠SD大鼠空腹血糖(FBG)和空腹胰岛素(FINS)指标的参考值上限。方法检索中国知网、万方、维普、Web of Science、The Cochrane Library、Scopus、PubMed、EMBase和MEDLINE共9个中英文数据库中与妊娠SD大鼠血糖有关文献,检索时限为2014年1月—2020年12月。严格按照纳入和排除标准,对检索到的文献进行筛选和数据提取。采用SYRCLE动物实验偏倚风险评估工具进行文献质量评价,以加权均数差(WMD)和95%可信区间(CI)作为合并统计量,应用STATA 15.0统计软件进行单组连续变量Meta分析。结果纳入37篇文献,包含428只大鼠。系统评价和Meta结果显示妊娠大鼠FBG和FINS的参考值上限分别为妊娠第0周的5.51 mmol/L(FBG)及无统计数据(FINS);第1周6.92 mmol/L (FBG)和15.66 m IU/L (FINS)、第2周的6.64 mmol/L(FBG)和15.98 m IU/L(FINS)及第3周的7.04 mmol/L(FBG)和15.63 m IU/L(FINS)。结论通过Meta分析确定妊娠SD大鼠FBG和FINS的参考值上限,为相关实验提供依据,以期减少实验误差。Objective To identify the reference limitation of fasting blood glucose( FBG) and fasting serum insulin( FINS) among pregnant SD rats. Method Three Chinese databases and 6 English databases were retrieved from January 2014 to December 2020 including CNKI,Wan Fang,VIP,Web of Science,The Cochrane Library,Scopus,PubMed,EmBase and MEDLINE. The data in these obtained references were extracted based on the inclusion and exclusion criteria. The quality of these references was evaluated by SYRCLE’s risk of bias tool for animal studies. The statistical software STATA 15. 0 was used to do the Meta-analysis of Single Group Continuous Variables. Weighted mean difference( WMD) and 95% confidence interval( CI) were used for combined statistic calculation. Result Four hundred and twenty-eight rats were included in these 37 articles. According to the systematic review and Meta-analysis,the upper reference limit of FBG and FINS on week 0,week 1,week 2 and week 3 among these pregnant rats were 5. 51 mmol/L( FBG) and no statistical data( FINS),6. 92 mmol/L( FBG)and 15. 66 m IU/L( FINS),6. 64 mmol/L( FGB) and 15. 98 m IU/L( FINS),together with 7. 04 mmol/L( FGB)and 15. 63 m IU/L( FINS),respectively. Conclusion The reference limitation of FBG and FINS among pregnant SD rats determined by Meta-analysis would guide the related experiments about detecting FBG and FINS among pregnant SD rats,and thus reduce the error among experiments in the future.

关 键 词：大鼠 血糖 妊娠 系统评价 META分析 

分 类 号：Q95-33[生物学—动物学]