慢性心力衰竭兔心室结构重构对心电生理功能产生的影响及意义  

Effect and Significance of Ventricular Structural Remodeling on Electrophysiological Function in Chronic Heart Failure Rabbits

作　　者：安晓霞 贺梅年 何秀英 AN Xiaoxia;HE Meinian;HE Xiuying(Department of Function,the Fifth People’s Hospital of Qinghai Province,Xining 810000,China;Department of Health Management,the Fifth People s Hospital of Qinghai Province,Xining 810000,China)

机构地区：[1]青海省第五人民医院功能科,西宁810000 [2]青海省第五人民医院健康管理科,西宁810000

出　　处：《实验动物科学》2021年第6期59-62,共4页Laboratory Animal Science

摘　　要：目的探讨慢性心力衰竭(CHF)兔心室结构重构对心电生理功能的影响及意义。方法雄性新西兰兔32只,随机分为对照组(n=15)和CHF组(n=17),CHF组采用经兔耳静脉注射异丙肾上腺素(ISO)制备CHF模型,最终造模成功15只。对照组给予相同体积的0.9%生理盐水,最终12只进入实验。采用超声心动图监测两组兔M型心功能并记录Ⅱ导联体表心电图,分别记录左心室射血分数(LVEF)、主动脉最大流速(Avmax)、左心室舒张末期内径(LVEDd)、左心室收缩末期内径(LVESD)、左室短轴缩短率(LVFS)、室间隔厚度(IVST)、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)、心率、PR间期、QT间期和ST段,评价心电生理功能变化。程控刺激法观察刺激周长(BCL)为_(150) ms和_(200) ms时,心室有效不应期(ERP_(150)和ERP_(200))以及各自有效不应期离散度(dERP_(150)和dERP_(200))。评价短阵快速刺激法诱发室性心律失常(VA)的BCL及诱发率。结果与对照组相比,CHF组兔的LVEF、LVFS及Avmax显著下降,LVEDd和LVESD明显延长,IVST较对照组变薄,LVEDV和LVESV明显增大,差异极显著(P<0.01);HR明显减慢,PR及QT间期显著延长,ST段明显下移,差异极显著(P<0.01);ERP _(150)和ERP_(200)明显延长,且dERP_(150)和dERP_(200)显著增大,诱发VA的BCL明显延长,VA诱发率明显高于对照组,差异极显著(P<0.01)。结论CHF兔心室结构发生显著的重构,心室电生理异常改变,二者相互作用,使折返性VA诱发率增加。Objective To investigate effect and implication of cardiac performance and electrophysiological induced by structural remodeling with chronic heart failure(CHF)in ventricular of rabbits.Method Thirty two male New Zealand rabbits were randomly divided into 2 groups:the control group(n=15)and the CHF group(n=17).The CHF group was used to prepare CHF model by injecting isoprenaline(ISO)into rabbit ear vein,and finally 15 rabbits were successfully made.The control group was given the same volume of 0.9%saline,and finally 12 rats entered the experiment.Echocardiography was used to monitor the M-type cardiac function of the 2 groups of rabbits,and leadⅡECG was recorded.LVEF,Avmax,LVEDd,LVESD,shortening rate of left ventricular short axis were recorded(LVFS),interventricular septal thickness(IVST),left ventricular end diastolic volume(LVEDV)and left ventricular end systolic volume(LVESV),as well as heart rate,PR interval,QT interval and ST segment,were used to evaluate the changes of ECG physiological function.Programmed stimulation was used to observe the effective refractory period and dispersion of each effective refractory period when the stimulation perimeter(BCL)was _(150) ms and _(200) ms.To evaluate the BCL and the rate of ventricular arrhythmia(VA)induced by burst packing.Result Compared with the control group,LVEF,LVFS and Avmax of the CHF group were significantly lower,LVEDd and LVESD were significantly longer.IVST was thinner than that of the control group.LVEDV and LVESV were significantly higher than that of the control group(P<0.01).HR of CHF group was significantly slower than that of the control group(P<0.01).PR and QT intervals were significantly longer than that of the control group(P<0.01).ST segment was significantly lower than that of the control group(P<0.01).The difference was statistically significant.In the CHF group,ERP_(150) and ERP_(200) were significantly longer than those in the control group,and both of dERP _(150) and dERP_(200) were significantly larger than those in the control group

关 键 词：慢性心力衰竭 结构重构 心电生理功能 心律失常 

分 类 号：Q95-33[生物学—动物学]