葡萄糖转运蛋白(GLUT)的研究进展  

Research Progress of Glucose Transporter(GLUT)

作　　者：许翊坤 王显仪 吴家玮 许琳枫 陆晟迪 马中良[1] XU Yi-kun;WANG Xian-yi;WU Jia-wei;XU Lin-feng;LU Sheng-di;MA Zhong-liang(Lab for Noncoding RNA&Cancer,School of Life Sciences,Shanghai University,Shanghai 200444,China;QianWeichang School,Shanghai University,Shanghai 200444,China;Department of Orthopaedics,Shanghai Jiao Tong University Affiliated No.6 People's Hospital,Shanghai 200233,China)

机构地区：[1]上海大学生命科学学院非编码RNA与癌症实验室,上海200444 [2]上海大学钱伟长学院,上海200444 [3]上海交通大学附属上海市第六人民医院骨科,上海200233

出　　处：《药物生物技术》2021年第6期655-659,共5页Pharmaceutical Biotechnology

摘　　要：维持葡萄糖稳态是机体复杂调节系统的结果,葡萄糖转运蛋白(Glucose Transporter,GLUT)在其中发挥重要作用。GLUT蛋白家族在疾病治疗中起到关键作用,例如可有效抑制多种类型肿瘤的发生,促进糖尿病导致的创面愈合等。文章对转运蛋白中的GLUT蛋白家族的结构与功能进行了阐述,并结合非编码RNA对GLUT的调控,阐明了其在肿瘤和糖尿病治疗中的具体作用机制,为GLUT在精准医疗中发挥作用提供了参考。Maintenance of glucose homeostasis was the result of a complex regulatory system.GLUT(glucose transporter)protein family plays a significant role in disease treatment,such as tumors and diabetes.In this paper,GLUT protein family transporters,specifically its structure and function was reviewed.Combined with the regulation of GLUT by non-coding RNA,the specific mechanism of glucose transporter in the treatment of tumor and diabetes was elucidated in this paper,so as to provide a reference for GLUT to play a role in precision medicine.

关 键 词：葡萄糖转运蛋白 非编码RNA 肿瘤 糖尿病 精准医疗 

分 类 号：Q51[生物学—生物化学]