人体刚地弓形虫感染对血脂水平的影响  

Impact of Toxoplasma gondii human infections on blood lipid levels

作　　者：吴力丰 叶旭芳 WU Li-feng;YE Xu-fang(Department of Laboratory Medicine,The First People’s Hospital of Linping District,Hangzohu City,Hangzhou,Zhejiang 311100,China)

机构地区：[1]浙江省杭州市临平区第一人民医院检验科,浙江杭州311100

出　　处：《中国血吸虫病防治杂志》2021年第6期639-642,共4页Chinese Journal of Schistosomiasis Control

摘　　要：目的分析人体刚地弓形虫感染对血脂水平的影响。方法以2017年1月至2019年12月某三级医院1000例体检健康者作为研究对象,根据酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)是否检出血清抗弓形虫抗体分为感染组和对照组,检测并比较两组研究对象血清总胆固醇(total cholesterol,TC)、高密度脂蛋白(high-density lipoprotein,HDL)、低密度脂蛋白(low-density lipoprotein,LDL)和甘油三酯(triglyceride,TG)水平。结果1000例研究对象血清抗弓形虫抗体阳性率为8.40%,感染组和对照组研究对象性别(χ^(2)=1.29,P>0.05)和年龄构成(χ^(2)=1.41,P>0.05)差异均无统计学意义。感染组研究对象血清LDL和TC均值显著高于对照组(t=3.89、3.81,P均<0.05),但两组研究对象血清TG和HDL差异均无统计学意义(t=0.97、0.75,P均>0.05);感染组研究对象LDL和TC值不正常比例均显著高于对照组(χ^(2)=9.69、10.39,P均<0.01),但两组研究对象TG和HDL值不正常比例差异均无统计学意义(χ^(2)=0.02、0.11,P均>0.05)。结论人体刚地弓形虫感染影响血脂水平变化,血清抗弓形虫抗体阳性者平均LDL和TC值及TC和LDL值不正常比例均显著高于抗体阴性者。Objective To evaluate the impact of Toxoplasma gondii human infections on blood lipid levels.Methods A total of 1000 healthy volunteers that were randomly sampled from a tertiary hospital during the period from December 2017 through December 2019 were enrolled,and assigned into the infection group and the control group according to the detection of serum anti-T.gondii antibody using enzyme-linked immunosorbent assay(ELISA).The serum levels of total cholesterol(TC),highdensity lipoprotein(HDL),low-density lipoprotein(LDL)and triglyceride(TG)were detected and compared between the two groups.Results The seroprevalence of anti-T.gondii antibody was 8.40%in the study subjects,and there were no significant differences between the infection and control groups in terms of gender(χ^(2)=1.29,P>0.05)or age(χ^(2)=1.41,P>0.05).The mean serum LDL(t=3.89,P<0.05)and TC levels(t=3.81,P<0.05)were significantly higher in the infection group than in the control group,while no significant differences were seen between the two groups in terms of mean serum TG(t=0.97,P>0.05)or HDL levels(t=0.75,P>0.05).In addition,the proportions of abnormal LDL(χ^(2)=9.69,P<0.01)and TC levels(χ^(2)=10.39,P<0.01)were significantly greater in the infection group than in the control group,while no significant differences were found in the proportion of abnormal TG(χ^(2)=0.02,P>0.05)or HDL level(χ^(2)=0.11,P>0.05)between the two groups.CCoonncclluu-sion T.gondii human infections affect blood lipid levels,and the individuals sero-positive for anti-T.gondii antibody have higher mean serum LDL and TC,as well as higher proportions of abnormal TC and LDL than sero-negative individuals.

关 键 词：刚地弓形虫 血脂 总胆固醇 高密度脂蛋白 低密度脂蛋白 甘油三酯 

分 类 号：R382.9[医药卫生—医学寄生虫学]