血清IL-5及TGF-β2水平对慢性分泌性中耳炎患者咽鼓管球囊扩张术疗效的预测价值  

Value of serum IL-5 and TGF-β2 levels in predicting therapeutic effect of balloon dilatation of eustachian tube for chronic secretory otitis media

作　　者：闫迎春 李迎 李雪畅 Yan Yingchun;Li Ying;Li Xuechang(Department of Otolaryngology,Zhoukou Maternal and Child Health Hospital,Zhoukou 466000,China)

机构地区：[1]河南省周口市妇幼保健院耳鼻喉科,466000

出　　处：《中国实用医刊》2021年第23期52-55,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨血清白细胞介素-5(IL-5)、转化生长因子-β2(TGF-β2)水平对慢性分泌性中耳炎(CSOM)患者咽鼓管球囊扩张术(BET)疗效的预测价值。方法前瞻性选择2019年2月至2020年2月周口市妇幼保健院拟行BET治疗的136例CSOM患者为研究对象,入院时测定血清IL-5、TGF-β2水平,实施BET治疗。术后随访12个月,评估BET的治疗效果。比较不同治疗效果CSOM患者的基线资料和入院时血清IL-5、TGF-β2水平。分析入院时血清IL-5、TGF-β2水平预测CSOM患者BET治疗效果的价值。结果136例CSOM患者均完成BET治疗,治愈49例,好转67例,纳入有效组;无效20例,纳入无效组。无效组血清IL-5、TGF-β2水平均高于有效组(P均<0.05)。绘制受试者工作特征曲线图,结果显示,入院时血清IL-5、TGF-β2水平单独及联合预测CSOM患者BET治疗无效的曲线下面积分别为0.851、0.812、0.919,均有一定预测价值。结论血清IL-5、TGF-β2水平预测CSOM患者BET治疗失败具有一定的价值。Objective To investigate the value of serum interleukin-5(IL-5)and transforming growth factor-β2(TGF-β2)levels in predicting the therapeutic effect of balloon dilatation of eustachian tube(BET)for chronic secretory otitis media(CSOM).Methods A total of 136 patients with CSOM who were going to have BET treatment in Zhoukou Maternal and Child Health Hospital from February 2019 to February 2020 were prospectively selected as the study subjects.Serum IL-5 and TGF-β2 levels were measured at admission,and the patients were treated by BET.All patients were followed up for 12 months,and the therapeutic effect of BET was evaluated.The baseline data,serum IL-5 and TGF-β2 levels at admission in CSOM patients with different therapeutic effects were compared.The value of serum IL-5 and TGF-β2 levels at admission in predicting the therapeutic effect of BET in patients with CSOM was analyzed.Results One hundred and thirty-six patients with CSOM all completed BET treatment;49 cases were cured,and 67 cases were improved,and they were included into the effective group;while 20 cases were ineffective,and they were included into the ineffective group.Serum IL-5 and TGF-β2 levels in ineffective group were higher than those in effective group(all P<0.05).The receiver operating characteristic curve was drawn,and the results showed that the area under the curve of serum IL-5 and TGF-β2 levels at admission alone and in combination in predicting the ineffective BET treatment for patients with CSOM were 0.851,0.812 and 0.919,respectively,all of which had certain predictive value.Conclusions Serum IL-5 and TGF-β2 levels have certain predictive value in predicting the failure of BET treatment for patients with CSOM.

关 键 词：分泌性中耳炎 咽鼓管球囊扩张术 白细胞介素-5 转化生长因子-Β2 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]