唐山市超重和肥胖儿童尿酸水平与心血管危险因素关系分析  

Relationship between uric acid level and cardiovascular risk factors in overweight and obese children in Tangshan City

作　　者：李丹[1] 孙国华[1] 陈新春[1] 寇永妹[1] LI Dan;SUN Guo-hua;CHEN Xin-chun;KOU Yong-mei(Department of pediatrics,Tangshan Municipal People's Hospital,Tangshan,Hebei 063001,China)

机构地区：[1]唐山市人民医院儿科,河北唐山063001

出　　处：《中华全科医学》2022年第1期157-160,共4页Chinese Journal of General Practice

基　　金：河北省医学科学研究课题(20191599)。

摘　　要：目的了解唐山市超重、肥胖儿童尿酸水平与心血管危险因素间的关系,为预防高尿酸血症、降低心血管疾病罹患风险提供理论依据。方法以2018-2019年唐山市学龄儿童体检筛查出的560例超重、肥胖儿童为研究对象,测量身高、体重、腰围、血压(BP),计算体重指数;检测尿酸(UA)、空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。以性别分层,采用偏相关分析、logistic回归分析UA与心血管危险因素间的关系。结果(1)男、女生高尿酸血症检出率分别为36.50%、26.26%(P<0.05);(2)随UA水平增高,男生SBP、DBP升高、HDL-C下降,女生SBP、FPG、TC、TG、LDL-C升高、HDL-C下降,组间差异有统计学意义(均P<0.05);(3)男生UA水平与HDL-C负相关(r=-0.154,P<0.05)、与TG、SBP正相关(r=0.141、0.238,均P<0.05),女生UA水平与HDL-C负相关(r=-0.700,P<0.05)、与LDL-C、TG正相关(r=0.615、0.341,均P<0.05);(4)男生高尿酸血症的影响因素为年龄、低HDL-C血症、空腹血糖异常、超重/肥胖;女生高尿酸血症的影响因素为年龄、高TC血症、低HDL-C血症、高TG血症、超重/肥胖、高血压。结论唐山地区超重、肥胖儿童UA水平与心血管危险因素相关;应定期监测超重、肥胖儿童尿酸水平变化。Objective To understand the relationship between uric acid level and cardiovascular risk factors in overweight and obesity children in Tangshan,and to provide theoretical basis for preventing hyperuricemia and reducing the risk of cardiovascular disease.Methods Total 560 overweight and obesity children screened by physical examination of school-age children in Tangshan City from 2018 to 2019 were taken as the research objects.Height,weight,waist circumference(WC),blood pressure(BP)were measured,body mass index(BMI)was calculated.Uric acid(UA),fasting blood glucose(FPG),total cholesterol(TC),triglycerides(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)were detected.The relationship between uric acid and cardiovascular risk factors was analyzed by sex stratification.Results(1)The detection rates of boys and girls hyperuricemia were 36.50%and 26.26%respectively(P<0.05).(2)With the increase of UA level,SBP and DBP increased and HDL-C decreased in boys,SBP,FPG,TC,TG,LDL-C increased and HDL-C decreased in girls,the difference between groups was statistically significant(all P<0.05).(3)UA level in boys was negatively correlated with HDL-C(r=-0.154,P<0.05),positively correlated with TG and SBP(r=0.141,0.238,all P<0.05),meanwhile UA level in girls was negatively correlated with HDL-C(r=-0.700,P<0.05),and positively correlated with LDL-C and TG(r=0.615,0.341,all P<0.05).(4)The influencing factors of hyperuricemia in boys were age,low HDL-C,abnormal fasting blood glucose,overweight/obesity,meanwhile the influencing factors of hyperuricemia in girls were age,high TC,low HDL-C,high TG,overweight/obesity and hypertension.Conclusion UA level of overweight and obesity children in Tangshan City is related to cardiovascular risk factors.Uric acid levels of overweight and obesity children should be monitored regularly.

关 键 词：超重 肥胖 尿酸 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病] R446[医药卫生—内科学]