腹膜透析患者透析液中SGLT1、TGF-β1、VEGF水平与腹膜纤维化的关系及应用价值  

The correlation between peritoneal fibrosis and the levels of SGLT1,TGF-β1,and VEGF in peritoneal dialysis patients and its application value

作　　者：王超超 林永强 陈恬恬 周莹[2] 蔡小巧 林胜芬 WANG Chao-chao;LIN Yong-qiang;CHEN Tian-tian;ZHOU Ying;CAI Xiao-qiao;LIN Sheng-fen(Nephrology Department,Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine,Wenzhou,Zhejiang 325000,China;不详)

机构地区：[1]温州市中西医结合医院肾内科,浙江温州325000 [2]温州医科大学附属第一医院肾内科,浙江温州325000

出　　处：《中华全科医学》2022年第2期251-254,共4页Chinese Journal of General Practice

基　　金：浙江省基础公益研究计划项目(LQ19H050002)。

摘　　要：目的探讨腹透液中钠-葡萄糖转运体1(SGLT1)、转化生长因子-β1(TGF-β1)、血管内皮生长因子(VEGF)水平与腹膜纤维化的关系及其应用价值。方法选取2012年6月-2021年6月温州市中西医结合医院收治的发生腹膜纤维化的腹膜透析患者25例为研究组,另选取未发生腹膜纤维化的腹膜透析患者35例为对照组,比较2组SGLT1、TGF-β1、VEGF水平,分析SGLT1、TGF-β1、VEGF在腹膜纤维化诊断中的应用价值。结果研究组与对照组比较,SGLT[(128.85±22.58)pg/mL vs.(85.42±15.68)pg/mL],TGF-β1[(432.32±54.18)pg/mL vs.(245.72±32.10)pg/mL],VEGF[(903.25±61.45)ng/mL vs.(612.85±32.10)ng/mL]差异有统计学意义(均P<0.05)。经ROC曲线分析可知,腹透液中SGLT1、TGF-β1、VEGF联合诊断时可获得最大曲线下面积(AUC)为0.865(95%CI:0.708~0.952),敏感度、特异度为85.02%、82.14%。结论SGLT1、TGF-β1、VEGF水平异常升高与腹膜纤维化的发生有密切的关系,可有效预测腹膜纤维化发生情况。Objective To investigate the correlation between peritoneal fibrosis and the levels of sodium-glucose transporter 1(SGLT1),transforming growth factor-β1(TGF-β1),vascular endothelial growth factor(VEGF)and its application value.Methods Twenty-five cases of patients with peritoneal fibrosis on maintenance hemodialysis were selected as study group,and 35 cases of peritoneal dialysis patients without peritoneal fibrosis were selected as the control group in Department of Nephrology,Wenzhou Integrated Traditional Chinese and Western Medicine Hospital from June 2012 to June 2021.The levels of SGLT1,TGF-β1 and VEGF of two groups were compared.The application value of SGLT1,TGF-β1,and VEGF of diagnosis of peritoneal fibrosis were analyzed by diagnosis of peritoneal fibrosis.Results The levels of SGLT[(128.85±22.58)pg/mL vs.(85.42±15.68)pg/mL],TGF-β1[(432.32±54.18)pg/mL vs.(245.72±32.10)pg/mL],and VEGF[(903.25±61.45)ng/mL vs.(612.85±32.10)ng/mL]were statistically different between the two groups(all P<0.05).The ROC curve analysis showed that the maximum area under the curve(AUC)were 0.865(95%CI:0.708-0.952),and the sensitivity and specificity were 85.02%and 82.14%when the three were diagnosed jointly.Conclusion Abnormally elevated levels of SGLT1,TGF-β1,and VEGF are closely related to the occurrence of peritoneal fibrosis.The levels of SGLT1,TGF-β1,and VEGF can effectively predict the occurrence of peritoneal fibrosis.

关 键 词：腹膜透析 腹膜纤维化 钠-葡萄糖转运体1 转化生长因子-Β1 血管内皮生长因子 相关性 

分 类 号：R459.5[医药卫生—治疗学] R572.2[医药卫生—临床医学]