清热利湿化痰通络开玄方治疗脑梗死后遗症期的临床疗效及其炎性机制研究  

Clinical Efficacy and Inflammatory Mechanism of Qingre Lishi Huatan Tongluo Kaixuan Recipe in Treatment of Sequelae of Cerebral Infarction

作　　者：张雅雯 赵蕊 张紫微[2] 唐瑞雨 邓欢 边文静[2] 冯瑞雪[2] 张再康 ZHANG Ya-wen;ZHAO Rui;ZHANG Zi-wei;TANG Rui-yu;DENG Huan;BIAN Wen-jing;FENG Rui-xue;ZHANG Zai-kang(HealthClinic of Shijiazhuang No.4 Cadres′Sanatorium,Shijiazhuang 050080)

机构地区：[1]石家庄第四干休所卫生所,石家庄050080 [2]河北中医学院,石家庄050091

出　　处：《河北中医药学报》2022年第1期9-12,共4页Journal of Hebei Traditional Chinese Medicine and Pharmacology

基　　金：国家中医药管理局和河北省共建学科资助项目:No.2020033024;河北省社会科学基金项目:No.HB21ZX010;河北省社会科学发展研究课题:No.20200202040;河北省中医药管理局科研计划项目:No.2021112;河北中医学院校级重点培育学科项目:No.2020030463;河北中医学院科研能力提升一般项目:No.KTY2019047。

摘　　要：目的:研究清热利湿化痰通络开玄方对脑梗死后遗症期患者的临床疗效及其可能的作用机制。方法:选取患者60例,随机分成对照组(常规西药治疗)和研究组(常规西药加清热利湿化痰通络开玄方治疗)各30例。对比分析治疗前和治疗后2组神经功能缺损评分[采用美国国立卫生研究院卒中量表(NIHSS)]、中医症状评分、血清炎性因子[白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]。结果:研究组总有效率为86.67%,对照组总有效率为70.00%,研究组高于对照组,差异有显著性(P<0.05)。研究组NIHSS评分、中医症状评分均低于对照组,差异均有显著性(P<0.05);研究组血清炎性因子(IL-6、TNF-α)均低于对照组,差异具有显著性(P<0.05)。结论:清热利湿化痰通络开玄方对脑梗死后遗症期患者具有良好疗效,能够促进神经功能恢复和中医症状的改善,其作用机制可能与抑制炎症反应有关。Objective:To study the clinical effect and possible mechanism of Qingre Lishi Huatan Tongluo Kaixuan Recipe on patients with sequelae of cerebral infarction.Methods:60 patients were randomly divided into control group(conventional western medicine treatment)and study group(conventional western medicine plus Qingre Lishi Huatan Tongluo Kaixuan Recipe treatment)with 30 cases in each group.The neurological deficit score[using the National Institutes of Health Stroke Scale(NIHSS)],TCM symptom score,serum inflammatory factor[interleukin-6(IL-6)and tumor necrosis factor(TNF-α)]of the two groups before and after treatment were compared and analyzed.Results:The total effective rate was 86.67%in the study group and 70.00%in the control group.The difference was significant(P<0.05).NIHSS score and TCM symptom score in the study group were lower than those in the control group(P<0.05);IL-6 and TNF-αin the study group were lower than those in the control group,and the difference was significant(P<0.05).Conclusion:Qingre Lishi Huatan Tongluo Kaixuan Recipe has a good curative effect on patients with sequelae of cerebral infarction,and can promote the recovery of neurological function and the improvement of TCM symptoms.Its mechanism may be related to the inhibition of inflammatory reaction.

关 键 词：脑梗死后遗症期 中风 清热利湿化痰通络开玄方 玄府郁闭 玄府理论 白介素-6 肿瘤坏死因子-α 

分 类 号：R255.2[医药卫生—中医内科学]