从过咸伤肾探讨糖尿病肾脏损害的发病机制  

Discussion about Diabetic Kidney Disease Injury Based on the Theory of Excessive Salt Hurting Kidney

作　　者：汪晓露 赵勇[2] 左新河[1,2] WANG Xiaolu;ZHAO Yong;ZUO Xinhe(Hubei Universita of Chinese Medicine,Wuhan Hubei China 430061;Hubei Provincial Hospital of Chinese Medicine,Wuhan Hubei China 430061)

机构地区：[1]湖北中医药大学,湖北武汉430061 [2]湖北省中医院,湖北武汉430061

出　　处：《中医学报》2022年第3期496-501,共6页Acta Chinese Medicine

基　　金：学术流派传承工作室第二轮建设项目{国中医药人教函[2019]62号};陈如泉全国名中医传承工作室建设项目{国中医药办人教函[2018]119号}。

摘　　要：糖尿病肾脏损害为糖尿病常见的并发症,中医脏象理论有"咸入肾""过咸伤肾"等理论。糖尿病及糖尿病肾脏损害患者均被限制食盐的摄入量,高盐的摄入对糖尿病肾脏损害的影响和作用机制具有复杂性和多样性,可以引起微量白蛋白尿的发生与发展、损害肾功能、升高血压,加重糖尿病肾脏损害。高盐摄入主要通过激活肾素-血管紧张素-醛固酮系统、引起糖脂代谢紊乱及上皮钠离子通道等参与糖尿病肾脏损害的发生与发展。Diabetic kidney disease injury is a common complication of diabetes.The visceral manifestation theory of Chinese medicine has the theory of"salt into the kidney"and"excessive salt hurting kidney".Patients with diabetes and diabetic kidney injury are all restricted by the intake of salt.The effects and mechanisms of high salt intake on diabetic kidney injury are complex and diverse,which can cause the occurrence and development of microalbuminuria,damage kidney function,increase hypertension and aggravate kidney injury in patients with diabetic kidney diseas.High salt intake mainly participates in the occurrence and development of diabetic kidney injury by activating the rennin-angiotensin-aldosterone system,causing glucose and lipid metabolism disorders and epithelial sodium channels.

关 键 词：糖尿病肾脏损害 过咸伤肾 消渴 中医脏象理论 高盐摄入 

分 类 号：R255.4[医药卫生—中医内科学]