益脾补肾滋养方联合长效促性腺激素释放激素激动剂对冻融胚胎移植患者妊娠结局的影响  

Effect of Yipi Bushen Ziyang Fang Combined with Long-Acting Gonadotropin-Releasing Hormone Agonist on Pregnancy Outcome of Frozen Embryo Transfer Patients

作　　者：赵艳晓[1] 赵瑞钦 毕晓英 ZHAO Yanxiao;ZHAO Ruiqin;BI Xiaoying(The Third Hospital Affiliated to Henan University of Chinese Medicine,Zhengzhou Henan China 450000)

机构地区：[1]河南中医药大学第三附属医院,河南郑州450000

出　　处：《中医学报》2022年第3期614-619,共6页Acta Chinese Medicine

基　　金：国家自然科学青年基金项目(61802350)。

摘　　要：目的:观察益脾补肾滋养方联合长效促性腺激素释放激素激动剂(gonadotrophin releasinghormone agonist, GnRH-a)对冻融胚胎移植(frozen embryo transfer, FET)患者妊娠结局的影响。方法:采用前瞻性分析的研究方法,112例FET患者按照随机数字表法分为观察组和对照组,每组各56例。对照组给予GnRH-a治疗,观察组在对照组治疗基础上给予益脾补肾滋养方。比较两组患者治疗后子宫情况、转化日内膜和子宫动脉血流情况、妊娠结局和新生儿结局。结果:与对照组比较,观察组患者子宫内膜厚度、雌二醇水平均升高,子宫内膜增殖时间缩短,差异有统计学意义(P<0.05);与对照组比较,观察组的转化日内膜血流中血流指数(flow index, FI)、血管血流指数(vascular flow index, VFI)水平升高,转化日子宫动脉血流的阻力指数(resistance index, RI)、搏动指数(pulsatility index, PI)水平降低,差异有统计学意义(P<0.05);与对照组比较,观察组移植胚胎数、多胎妊娠率较少,胚胎复苏率、胚胎种植率、临床妊娠率均升高,差异有统计学意义(P<0.05);与对照组比较,观察组孕妇胎盘早剥、胎膜早破、早产发生率均降低,差异有统计学意义(P<0.05);与对照组比较,观察组新生儿死胎死产、胎儿畸形发生率均降低,差异有统计学意义(P<0.05)。结论:益脾补肾滋养方联合GnRH-a可有效改善FET妇女子宫情况和转化日子宫内膜、动脉血流情况,改善妊娠结局,降低胎膜早破率和早产率,改善新生儿死胎死产、胎儿畸形情况。Objective: To observe the effect of Yipi Bushen Ziyang Fang combined with long-acting gonadotropin releasing hormone agonist(GnRH-a) on pregnancy outcome in patients with frozen embryo transfer(FET).Methods: Using the research method of prospective analysis, 112 FET patients were randomly divided into observation group and control group, with 56 cases in each group.The control group was treated with GnRH-a, and the observation group was treated with Yipi Bushen Ziyang Fang on the basis of the treatment of the control group.The uterine condition, endometrial and uterine artery blood flow on the day of transformation, pregnancy outcome and neonatal outcome were compared between the two groups.Results: Compared with the control group, the endometrial thickness and estradiol level in the observation group were increased, and the endometrial proliferation time was shortened, and the difference was statistically significant(P<0.05);compared with the control group, the levels of flow index(FI) and vascular flow index(VFI) in endometrial blood flow on the day of transformation in the observation group increased, and the levels of resistance index(RI) and pulsatility index(PI) of uterine artery blood flow on the day of transformation decreased(P<0.05);compared with the control group, the number of transferred embryos and multiple pregnancy rate in the observation group were less, and the embryo resuscitation rate, embryo implantation rate and clinical pregnancy rate were higher in the observation group(P<0.05);compared with the control group, the incidence of placental abruption, premature rupture of membranes and premature delivery in the observation group were significantly lower(P<0.05);compared with the control group, the incidence of neonatal stillbirth and fetal malformation in the observation group decreased, and the difference was statistically significant(P<0.05).Conclusion: Yipi Bushen Ziyang Fang combined with GnRH-a can effectively improve the uterine condition of FET women and the endometrial and arterial blo

关 键 词：冻融胚胎移植 益脾补肾滋养方 长效促性腺激素释放激素激动剂 妊娠结局 

分 类 号：R271.41[医药卫生—中医妇科学]