中重度阻塞性睡眠呼吸暂停对急性冠脉综合征患者心脏结构和功能的影响  

Effect of moderate and severe obstructive sleep apnea on cardiac structure and function in patients with acute coronary syndrome

作　　者：张娟[1] 王萍 周洁 吴国霞[1] 王立新[1] ZHANG Juan;WANG Ping;ZHOU Jie;WU Guoxia;WANG Lixin(Department of Respiratory Medicine,Beijing Yanqing District Hospital(Peking University Third Hospital Yanqing),Beijing102100,China)

机构地区：[1]北京市延庆区医院(北京大学第三医院延庆医院)呼吸内科,北京102100

出　　处：《中国当代医药》2022年第4期72-74,共3页China Modern Medicine

摘　　要：目的探讨中重度阻塞性睡眠呼吸暂停对急性冠脉综合征患者心脏结构和功能的影响。方法选取2018年6月至2020年6月北京市延庆区医院(北京大学第三医院延庆医院)收治的220例急性冠脉综合征患者作为研究对象,根据多导睡眠监测检查结果分为无/轻度组(52例)与中/重度组(168例)。比较两组的超声心动图相关指标。结果中/重度组患者的左心室舒张末期内径、二尖瓣口舒张早期最大血流峰值(E峰)、二尖瓣血流最大流速(E)与心房收缩期二尖瓣血流最大流速(A)的比值(E/A)低于无/轻度组,室间隔厚度、左心房内径、二尖瓣舒张晚期流速峰值(A峰)高于较无/轻度组,差异有统计学意义(P<0.05)。结论中重度阻塞性睡眠呼吸暂停能明显加重急性冠脉综合征患者的心脏重构,影响心室的舒张功能。Objective To investigate the effect of moderate and severe obstructive sleep apnea on cardiac structure and function in patients with acute coronary syndrome.Methods A total of 220 patients with acute coronary syndrome treated in Beijing Yanqing District Hospital(Peking University Third Hospital Yanqing)from June 2018 to June 2020 were selected as the research objects.According to the results of polysomnography,they were divided into no/mild group(52 cases)and medium/severe group(168 cases).The echocardiographic indexes of the two groups were compared.Results The left ventricular end diastolic diameter,E peak maximum flow rate(E)and ratio of maximal velocity of mitral orifice to maximum velocity of atrial contraction(E/A)in the moderate/severe group were lower than those in the non/mild group,and the ventricular septal thickness,left atrial diameter and A peak maximum flow rate(A)were higher than those in the non/mild group,the differences were statistically significant(P<0.05).Conclusion Moderate and severe obstructive sleep apnea can significantly aggravate cardiac remodeling and affect ventricular diastolic function in patients with acute coronary syndrome.

关 键 词：阻塞性睡眠呼吸暂停 急性冠脉综合征 心脏结构 心脏功能 

分 类 号：R543.3[医药卫生—心血管疾病]