大剂量呋塞米联合氨茶碱治疗老年难治性心力衰竭的效果  

Effect of high-dose Furosemide combined with Aminophylline in the treatment of refractory heart failure in the elderly

作　　者：徐曌 刘兰 麦健 吴越 宋贵芳 张丽 周璐 刘燕霞 XU Zhao;LIU Lan;MAI Jian;WU Yue;SONG Guifang;ZHANG Li;ZHOU Lu;LIU Yanxia(The First Department of Internal Medicine,the Second People′s Hospital of Chongqing Liangjiang New Area,Chongqing400016,China)

机构地区：[1]重庆两江新区第二人民医院内一科,重庆400016

出　　处：《中国当代医药》2022年第4期86-88,92,共4页China Modern Medicine

摘　　要：目的探讨大剂量呋塞米联合氨茶碱治疗老年难治性心力衰竭的效果。方法选取2019年5月至2020年5月重庆两江新区第二人民医院内一科收治的118例老年难治性心力衰竭患者作为研究对象,采用随机数字表法将患者分为对照组(59例)与研究组(59例)。对照组患者应用大剂量呋塞米进行治疗,研究组患者应用大剂量呋塞米联合氨茶碱进行治疗。比较两组患者的临床治疗效果、心功能指标以及不良反应发生情况。结果研究组患者的总有效率高于对照组(P<0.05);两组患者治疗前的心功能状况比较,差异无统计学意义(P>0.05);两组患者治疗后的左室射血分数(LVEF)均高于治疗前,左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)均低于治疗前(P<0.05);研究组患者治疗后的LVEF高于对照组,LVEDD、LVESD均低于对照组(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论应用大剂量呋塞米联合氨茶碱治疗老年难治性心力衰竭,可明显提高患者的临床治疗效果,改善患者的心功能状况,可推广应用。Objective To investigate the effect of high-dose Furosemide combined with Aminophylline in the treatment of refractory heart failure in the elderly.Methods A total of 118 elderly patients with refractory heart failure who were admitted to the First Department of Internal Medicine,the Second People′s Hospital of Chongqing Liangjiang New Area from May 2019 to May 2020 were selected as subjects.The patients were divided into a control group(n=59)and a study group(n=59)by the random number table method.The patients in the control group were treated with high-dose Furosemide,and in the study group were treated with high-dose Furosemide combined with Aminophylline.The clinical treatment effect,cardiac function indicators and adverse reactions between the two groups were compared.Results The total effectiveness rate of the study group was higher than that in the control group(P<0.05).There were no significant differences in the cardiac function indicators between the two groups before treatment(P>0.05).After treatment,left ventricular ejection fraction(LVEF)levels of two groups were higher than those before treatment,and left ventricular end systolic diameter(LVESD)and left ventricular end diastolic diameter(LVEDD)levels of two groups were lower than those before treatment(P<0.05).After treatment,the LVEF of the study group was higher than that in the control group,the LVEDD and LVESD of the study group were lower than those in the control group after treatment(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of high-dose Furosemide combined with Aminophylline in the treatment of refractory heart failure in the elderly can significantly improve the clinical treatment effect of patients and improve the patients′cardiac function.It can be popularized and applied.

关 键 词：大剂量呋塞米 氨茶碱 老年难治性 心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]