血清促甲状腺激素受体抗体在三种甲状腺疾病临床诊断中的应用价值  

Analysis of the application value of serum thyroid stimulating hormone receptorantibody(ATSHR)in the clinical diagnosis of three kinds of thyroid diseases

作　　者：邓蔷 陈曦[1] 代春梅[1] 罗立梅[1] DENG Qiang;CHEN Xi;DAI Chun-mei(Department of clinical Laboratory,Mianyang Central Hospital,Sichuan Mianyang 621000)

机构地区：[1]绵阳市中心医院检验科,四川绵阳621000

出　　处：《医学检验与临床》2022年第1期21-23,共3页Medical Laboratory Science and Clinics

摘　　要：目的:探讨血清促甲状腺激素受体抗体(ATSHR)在三种甲状腺疾病临床诊断中的临床意义。方法:选取我院自2019年6月~2019年12月1006例甲状腺疾病患者为观察组,其中毒性弥漫性甲状腺肿(Graves病)420例、桥本甲状腺炎(Hashimotos thyroiditis)389例、甲状腺癌(Thyroid Cancer)197例,另选200名健康体检者设为对照组,对比两组血清ATSHR阳性率和ATSHR水平。结果:观察组ATSHR阳性率明显高于对照组(P<0.05);观察组中,Graves病患者ATSHR阳性率高于桥本甲状腺炎和甲状腺癌患者(P<0.05),对照组无ATSHR阳性(P>0.05);观察组血清ATSHR水平高于对照组(P<0.05);观察组中,Graves病患者水平显著高于桥本甲状腺炎和甲状腺癌患者(P<0.05)。结论:甲状腺疾病患者的血清促甲状腺激素受体抗体较健康人升高,在不同的甲状腺疾病患者中水平差异显著,尤其是Graves病患者的血清ATSHR水平升高最明显,对临床鉴别和诊断Graves病及筛查甲状腺疾病具有一定的价值。Objective:To investigate the serum thyroid stimulating hormone receptor antibody(ATSHR)in three kinds of thyroid disease in the clinical diagnosis of clinical significance.Methods:select our hospital from June 2019-December 20191006 cases of thyroid disease patients as observation group,including diffuse toxic goiter in 420 cases,389 cases of hashimoto thyroiditis,197 cases of thyroid cancer,an alternate 200 healthy physical examination were set as control group,compared two groups of serum ATSHR positive rate and ATSHR level.Results:observation group ATSHR positive rate is significantly higher than control group(P<0.05);In the observation group,Graves disease ATSHR positive rate higher than that of hashimoto thyroiditis and thyroid cancer patients(P<0.05),The control group without ATSHR positive(P>0.05);Observation group serum ATSHR level is higher than the control group(P<0.05);In the observation group,Graves disease were significantly higher than that of hashimoto thyroiditis and thyroid cancer patients(P<0.05).Conclusion:The patients with thyroid disease serum thyroid stimulating hormone receptor antibody higher than healthy people,at different levels of thyroid disease in patients with significant difference,especially in Graves disease ATSHR serum levels,the most obvious of clinical identification and diagnosis of Graves disease and screening for thyroid disease has a certain value.

关 键 词：甲状腺疾病 甲状腺激素受体抗体 GRAVES病 桥本甲状腺炎 甲状腺癌诊断 

分 类 号：R58[医药卫生—内分泌]