支原体肺炎患儿血清IL-6、SAA、hs-CRP、PCT联合检测的临床意义  

Clinical significance of combined detection of serum IL-6,SAA,hs-CRP and PCT in children with mycoplasma pneumonia

作　　者：王萍[1,2] 王静 丰新倩[2] WANG Ping;WANG Jing;FENG Xin-qian(Qingdao University School of Basic Medicine,Shandong Qingdao 266071)

机构地区：[1]青岛大学基础医学院,山东青岛266071 [2]淄博市第一医院检验科,山东淄博255200

出　　处：《医学检验与临床》2022年第1期32-35,共4页Medical Laboratory Science and Clinics

摘　　要：目的:探讨血清IL-6、SAA、hs-CRP、PCT联合检测在儿童肺炎支原体感染及其合并细菌、病毒感染中的鉴别诊断价值。方法:收集2017年8月~2019年12月在淄博市第一医院儿科收治的支原体肺炎患儿349例,感染组分为单纯MPP组161例、合并病毒感染组64例、合并细菌感染组94例,随机选取同期淄博市第一医院健康体检的儿童50例为健康对照组。各组患儿在入院初期留取咽拭子、痰液及血清分别进行MP-DNA检测、一般细菌培养和血清IL-6、SAA、hs-CRP、PCT的检测,分析各组患儿血清炎性因子的变化。结果:MPP组和MP合并细菌组IL-6、hs-CRP、PCT水平显著高于其它组(P<0.05),MP合并病毒组SAA水平明显升高,与其它组比,差异有统计学意义(P<0.05),MP组和MP合并细菌感染组比较,MP合并细菌感染组的IL-6、hs-CRP、PCT水平升高的程度更大,差异有统计学意义(P<0.05)。结论:血清IL-6、SAA、hs-CRP、PCT联合检测可作为支原体肺炎患儿是否合并有其它病原体感染的鉴别诊断指标,联合检测结果对病原学诊断、合理性用药指导及疗效评估、预后判断等具有实用价值。Objective:To explore the value of combined detection of serum IL-6,SAA,hs CRP,and PCT in the differential diagnosis of mycoplasma pneumoniae infection and its combined bacterial and viral infection in children.Methods:A total of 349 children with mycoplasma pneumonia in ZiBo First Hospital from August 2017 to December 2019 were collected.The infection group was divided into simple MP group(161 cases),the combined with virus infection group(64 cases),and the combined bacterial infection group(94 cases),Fifty healthy children undergoing physical examination in ZiBo First Hospital during the same period were randomly selected as the healthy control group.In each group,pharyngeal swabs,sputum and serum were collected for MP-DNA detection,general bacterial culture and serum IL-6,SAA,hs-CRP,and PCT detection,respectively,to analyze the changes of serum inflammatory factors in children in each group.Results:The levels of IL-6,hs CRP,and PCT in the MP group and the MP combined bacterial group were significantly higher than those in the other groups(P<0.05),and the SAA level in MP combined with virus group was significantly higher,compared with other groups,the difference was statistically significant(P<0.05).Compared with the MP group and the MP combined with bacterial infection group,the levels of IL-6,hs CRP,and PCT in MP combined with bacterial infection group were significant higher than those in MP group(P<0.05).Conclusion:The combined detection of serum IL-6,SAA,hs CRP,and PCT can be used as a differential diagnosis index for children with mycoplasma pneumonia complicated with other pathogens.The combined detection results have practical value for etiology diagnosis,rational medication guidance,efficacy evaluation,and prognosis judgment.

关 键 词：支原体肺炎 IL-6 SAA HS-CRP PCT 

分 类 号：R72[医药卫生—儿科]