COVID-19 emergency: Changes in quality of life perception in patients with chronic liver disease-An Italian single-centre study  

作　　者：Alessandra Zannella Silvia Fanella Massimo Marignani Paola Begini 

机构地区：[1]Department of Gastroenterology,Sant’Andrea Hospital,Rome 00189,Italy

出　　处：《World Journal of Hepatology》2022年第1期274-286,共13页世界肝病学杂志（英文版）（电子版）

基　　金：The study was conducted according to Sant’Andrea Hospital directives following Latium Region order(No.3405/2020 and 4888/2020,Regione.Lazio.Ufficiale UO54467/U0218196,11/03/2020).

摘　　要：BACKGROUND In December 2019,the coronavirus disease-2019(COVID-19)emerged and rapidly spread worldwide,becoming a global health threat and having a tremendous impact on the quality of life(QOL)of individuals.AIM To evaluate the awareness of patients with chronic liver disease(CLD)regarding the COVID-19 emergency and how it impacted on their QOL.METHODS Patients with an established diagnosis of CLD(cirrhosis,autoimmune hepatitis,primary biliary cholangitis,and primary sclerosing cholangitis)who had been evaluated at our Outpatient Liver Disease Clinic during the 6-mo period preceding the start of Italian lockdown(March 8,2020)were enrolled.Participants were asked to complete a two-part questionnaire,administered by telephone according to governmental restrictions:The first section assessed patients’basic knowledge regarding COVID-19,and the second evaluated the impact of the COVID-19 emergency on their QOL.We used the Italian version of the CLD questionnaire(CLDQ-I).With the aim of evaluating possible changes in the QOL items addressed,the questionnaire was administered to patients at the time of telephone contact with the specific request to recall their QOL perceptions during two different time points.In detail,patients were asked to recall these perceptions first during time 0(t0),a period comprising the 2 wk preceding the date of ministerial lockdown decree(from February 23 to March 7,2020);then,in the course of the same phone call,they were asked to recall the same items as experienced throughout time 1(t1),the second predetermined time frame encompassing the 2 wk(from April 6 to April 19)preceding our telephone contact and questionnaire administration.All data are expressed as number(%),and continuous variables are reported as the median(interquartile range).The data were compared using the Wilcoxon paired non-parametric test.RESULTS A total of 111 patients were enrolled,of whom 81 completed the questionnaire.Forty-nine had liver cirrhosis,and all of them had compensated disease;32 patients had autoimmune

关 键 词：COVID-19 Liver disease Quality of life Liver cirrhosis Chronic liver disease questionnaire 

分 类 号：R563.1[医药卫生—呼吸系统] R575[医药卫生—内科学]