Historical evolution,overview,and therapeutic manipulation of costimulatory molecules  

作　　者：Henry Velazquez-Soto Fernanda Real Maria C Jimenez-Martinez 

机构地区：[1]Department of Immunology and Research Unit,Institute of Ophthalmology“Conde de Valenciana”,Mexico City 06800,Mexico [2]Department of Biochemistry,Faculty of Medicine,National Autonomous University of Mexico,Mexico City 04510,Mexico

出　　处：《World Journal of Immunology》2022年第1期1-8,共8页世界免疫学杂志

基　　金：Supported by Institute of Ophthalmology“Fundacion Conde de Valenciana”;Velazquez-Soto H received fellowship 294674 from CONACYT during his doctoral studies in Programa de Doctorado en Ciencias Medicas,Odontologicas y de la Salud(Farmacologia Clinica),Universidad Nacional Autonoma de Mexico(UNAM);Real F with CVU 917729,recieved fellowship from CONACYT during his master studies in Programa de Maestria en Ciencias Medicas,Odontologicas y de la Salud(Farmacologia Clinica),Universidad Nacional Autonoma de Mexico(UNAM).

摘　　要：Co-stimulatory molecules are key mediators in the regulation of immune responses and knowledge of its different families,structure,and functions has improved in recent decades.Understanding the role of co-stimulatory molecules in pathological processes has allowed the development of strategies to modulate cellular functions.Currently,modulation of co-stimulatory and co-inhibitory molecules has been applied in clinical applications as therapeutic targets in diseases and promising results have been achieved.

关 键 词：Co-stimulatory molecules Immune modulation Monoclonal antibodies Biological therapy Autoimmune diseases Oncological diseases 

分 类 号：O62[理学—有机化学]