Clinical effect of methimazole combined with selenium in the treatment of toxic diffuse goiter in children  

作　　者：Xiao-Hong Zhang Gao-Pin Yuan Ting-Li Chen 

机构地区：[1]Department of Pediatric Endocrinology,Quanzhou Women and Children’s Hospital,Quanzhou 362000,Fujian Province,China

出　　处：《World Journal of Clinical Cases》2022年第4期1190-1197,共8页世界临床病例杂志

摘　　要：BACKGROUND The incidence of toxic diffuse goiter(Graves’disease)is higher in adolescents and preschool-aged children,with an upward trend.The incidence at 6–13 years of age is approximately 11.0%,and the incidences in men and women are 7.8%and 14.3%,respectively.AIM To explore the clinical effect of methimazole combined with selenium in the treatment of toxic diffuse goiter(Graves’disease)in children and its effect on serum anti-thyroglobulin antibody(TRAb)and anti-thyroid peroxidase antibody(TPOAb).METHODS A total of 103 children with Graves’disease treated in our hospital from January 2018 to June 2021 were divided into a traditional group and a combined group(15-20 mg methimazole orally given to children)and a combined group(50μg selenium added on the basis of traditional treatment)according to different treatment methods to explore the therapeutic effects of the two methods and to observe the changes in thyroid volume and serum TRAb,TPOAb,free thyroxine(FT4)and inflammatory factor levels before and after treatment.The time taken for FT4 to return to normal was compared between the two groups.RESULTS Treatment was significantly more effective in the combined group than in the traditional group(P<0.05).The thyroid volumes of the children in the two groups was measured before and after treatment.Thyroid volume decreased significantly after treatment in both groups,and the thyroid volume was significantly lower in the combined group than in the traditional group(P<0.05).The serum levels of interleukin-6(IL-6),IL-8,TRAb,TPOAb and FT4 in the two groups were detected before and after treatment.The levels of IL-6,IL-8,TRAb,TPOAb and FT4 were significantly lower in the combined group than in the traditional group(P<0.05).Follow-up of the children in the two groups showed that compared with the traditional group,it took less time for children in the combined group to return to the normal level(P<0.05).CONCLUSION Methimazole combined with selenium can effectively treat Graves’disease in children,reduce the ex

关 键 词：METHIMAZOLE SELENIUM CHILDREN Antithyroid globulin Anti-thyroid peroxidase antibody 

分 类 号：R725.8[医药卫生—儿科]