Unicentric Castleman disease was misdiagnosed as pancreatic mass:A case report  

作　　者：Hong-Yan Zhai Xin-Yuan Zhu Gui-Ming Zhou Li Zhu Dan-Dan Guo Hao Zhang 

机构地区：[1]Department of Ultrasound,Tianjin Medical University General Hospital,Tianjin 300005,China [2]Department of Cardivascular,Tianjin Medical University General Hospital,Tianjin 300005,China [3]Department of Cardivascular Surgery,Tianjin Medical University General Hospital,Tianjin 300005,China

出　　处：《World Journal of Clinical Cases》2022年第4期1278-1285,共8页世界临床病例杂志

摘　　要：BACKGROUND Castleman’s disease(CD)is a lymphatic proliferative disorder of unknown cause and is rarely seen clinically.It has been divided into unicentric and multicentric types.Unicentric CD(UCD)occurs as a solitary enlarged mass and mediastinal lymph nodes are the most common site.Surgical excision has proven to be curative for UCD.Multicentric CD(MCD)appears as a systemic disease with peripheral lymphadenopathy.MCD had a poor response to surgery and monoclonal antibodies with rituximab have become a research hotspot.CASE SUMMARY A 44-year-old woman presented with a pancreatic mass during routine physical examination.She had no obvious symptoms,such as fever,abdominal pain,abdominal distension,or jaundice.Ultrasound examination indicated a hypoechoic mass between the body of the pancreas,left lobe of the liver and stomach.It had a clear boundary,irregular shape,uneven echo,and no obvious blood flow signals.To clarify the diagnosis,contrast-enhanced ultrasound examination was performed,which showed a benign pancreatic lesion.Neuroendocrine or solid pseudopapillary tumor was a possible diagnosis.The patient underwent further contrast-enhanced computed tomography and contrastenhanced magnetic resonance imaging,which were suggestive of solid pseudopapillary tumor or neuroendocrine tumor.All the examinations failed to give a definitive diagnosis,and the patient underwent surgery.The final pathological and immunohistochemical results showed that the mass was CD.CONCLUSION This case highlights when lymphadenopathy is encountered clinically,CD should be considered and a biopsy should be performed.

关 键 词：Castleman’s disease LYMPHADENOPATHY Unicentric MULTICENTRIC Contrastenhanced ultrasound Case report 

分 类 号：R551.2[医药卫生—血液循环系统疾病]