Toxic epidermal necrolysis induced by ritodrine in pregnancy:A case report  

作　　者：Wen-Yu Liu Jia-Rong Zhang Xian-Ming Xu Tian-Yi Ye 

机构地区：[1]Department of Obstetrics and Gynecology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 201600,China [2]Department of Obstetrics and Gynecology,Zhongshan Hospital,Fudan University,Shanghai 200032,China

出　　处：《World Journal of Clinical Cases》2022年第4期1381-1387,共7页世界临床病例杂志

摘　　要：BACKGROUND Preterm birth accounts for about 12%of all pregnancies worldwide and is the leading cause of neonatal morbidity and mortality.In order to avoid premature birth and prolong gestational age,tocolytics are the first and the best choice.Ritodrine is the most commonly used tocolytic medication.However,side effects such as pulmonary edema,hypokalemia,and hyperglycemia are known.Here we report a rare but serious side effect–toxic epidermal necrolysis(TEN)–caused by ritodrine.CASE SUMMARY A woman(31 years,gravida 4,para 2)was hospitalized because of premature contractions at 27+6 wk of gestation.A skin rash with pruritus appeared at 32+3 wk of gestation after administration of ritodrine,indomethacin,and dexamethasone,and it spread throughout the whole body in 3 d,particularly the four limbs.After 11 d’treatment,she was diagnosed with TEN.An emergency cesarean section was performed immediately to deliver the baby and intensive symptomatic treatment was promptly commenced after delivery.She recovered from the severe condition without any sequelae except for slight pigmentation after symptomatic treatment.CONCLUSION When a skin rash appears during the administration of ritodrine,we are supposed to consider the risk of TEN.

关 键 词：Preterm birth RITODRINE Side effect TOCOLYTICS Toxic epidermal necrolysis Case report 

分 类 号：R714.2[医药卫生—妇产科学]