Direct antiglobulin test-negative autoimmune hemolytic anemia in a patient withβ-thalassemia minor during pregnancy:A case report  

作　　者：Yang Zhou Yi-Ling Ding Li-Juan Zhang Mei Peng Jian Huang 

机构地区：[1]Department of Obstetrics and Gynecology,The Second Xiangya Hospital,Central South University,Changsha 410011,Hunan Province,China

出　　处：《World Journal of Clinical Cases》2022年第4期1388-1393,共6页世界临床病例杂志

摘　　要：BACKGROUND Severe refractory anemia during pregnancy can cause serious maternal and fetal complications.If the cause cannot be identified in time and accurately,blind symptomatic support treatment may cause serious economic burden.Thalassemia minor pregnancy is commonly considered uneventful,and the condition of anemia rarely progresses during pregnancy.Autoimmune hemolytic anemia(AIHA)is rare during pregnancy with no exact incidence available.CASE SUMMARY We report the case of a 30-year-oldβ-thalassemia minor multiparous patient experiencing severe refractory anemia throughout pregnancy.We monitored the patient closely,carried out a full differential diagnosis,made a diagnosis of direct antiglobulin test-negative AIHA,and treated her with prednisone and intravenous immunoglobulin.The patient gave birth to a healthy full-term baby.CONCLUSION Coombs-negative AIHA should be suspected in cases of severe hemolytic anemia in pregnant patients with and without other hematological diseases.

关 键 词：Maternal anemia β-thalassemia minor Autoimmune hemolytic anemia Direct antiglobulin test PREGNANCY Case report 

分 类 号：R714.254[医药卫生—妇产科学]