Metabolically healthy obesity:Is it really healthy for type 2 diabetes mellitus?  

作　　者：Qi Wu Ming-Feng Xia Xin Gao 

机构地区：[1]Department of Endocrinology and Metabolism,Zhongshan Hospital,Fudan University,Shanghai 200032,China [2]Fudan Institute for Metabolic Disease,Fudan University,Shanghai 200032,China

出　　处：《World Journal of Diabetes》2022年第2期70-84,共15页世界糖尿病杂志（英文版）（电子版）

摘　　要：Metabolically healthy obese(MHO)individuals are reported to have a lower risk of developing cardiovascular diseases in comparison with individuals with metabolic syndrome.However,the association between MHO and type 2 diabetes(T2DM)is still controversial.Some studies indicated that MHO is a favorable phenotype for T2DM,but more studies showed that MHO individuals have an increased risk of developing T2DM compared with metabolically healthy normalweight individuals,especially among those who would acquire metabolically unhealthy obesity.This has been supported by finding insulin resistance and lowgrade inflammatory responses in MHO individuals with a tendency for impaired beta-cell dysfunction.Studies also showed that liver fat accumulation increased the risk of incidence of T2DM in MHO.Here,we reviewed current literature on the relationship between MHO and T2DM,discussed the determinants for the development of diabetes in MHO,and summarized the measures for the prevention of T2DM in MHO.

关 键 词：Metabolically healthy obesity Type 2 diabetes Non-alcoholic fatty liver diseases Insulin resistance Low-grade inflammatory status Beta-cell dysfunction 

分 类 号：R589.2[医药卫生—内分泌] R587.2[医药卫生—内科学]