靖远县乙型病毒性肝炎母婴传播阻断措施实施情况及效果  

Implementation and Effect Observation of Measures to Block Mother-to-child Transmission of Hepatitis B in Jingyuan

作　　者：张丽娜 芮执平 张晓丽 展宗瑛 ZHANG Li-na;RUI Zhi-ping;ZHANG Xiao-li;ZHAN Zong-ying(Jingyuan Center for Disease Control and Prevention,Jingyuan,Gansu,730600,China)

机构地区：[1]靖远县疾病预防控制中心,甘肃靖远730600

出　　处：《中国初级卫生保健》2022年第1期73-75,共3页Chinese Primary Health Care

基　　金：国家科技重大专项(2017ZX10103006)。

摘　　要：目的:研究甘肃省靖远县乙型病毒性肝炎(简称乙肝)母婴传播阻断措施的实施情况及效果,为进一步探索乙肝防控策略、制订乙肝防控措施提供建议。方法:调查2016年10月1日—2017年10月31日期间靖远县所有助产机构入院分娩的乙型肝炎表面抗原(HBsAg)阳性产妇所生的新生儿,并对新生儿进行随访,检测其HBsAg和乙型肝炎表面抗体(HBsAb)。结果:研究共纳入HBsAg阳性住院产妇所生新生儿131名,其在出生24 h内全部进行了乙肝免疫球蛋白(HBIG)和乙肝疫苗首针(HepB1)接种。新生儿乙肝病毒指尖血检测结果显示,HBsAg阳性者1人,母婴阻断失败率为0.76%(1/131);HBsAb阳性者101人,母婴阻断成功率为77.10%(101/131);HBsAg和HBsAb全部阴性者29人,母婴阻断成功但免疫失败率为22.14%(29/131)。结论:乙肝疫苗联合免疫球蛋白阻断乙肝母婴传播措施实施情况较好,阻断HBsAg阳性母亲垂直传播乙肝病毒效果显著。OBJECTIVE To study the implementation and effect of mother-to-child transmission blocking measures of hepatitis B in Jingyuan of Gansu province,to further explore the effective strategy of prevention and control measures of hepatitis B and formulate hepatitis B prevention and control measures to provide suggestions.METHODS It investigated the newborns born to HBsAg-positive women who were admitted to the hospital in all midwifery institutions throughout the country from October 1,2016 to October 31,2017,and followed up the newborns to test their HBsAg and HbsAb.RESULTS 131 newborns born to HBsAg-positive hospitalized women,who all received hepatitis B immunoglobulin(HBIG)and the first who did hepatitis B vaccine(HepB1)within 24 hours of birth.Blood test results of neonatal hepatitis B virus showed that one HBsAg was positive,and the maternal-child block failure rate was 0.76%(1/131),101 HBsAg positive patients had a success rate of 77.10%(101/131),29 HBsAg and HBsAb negative patients had a success rate of mother-to-child occlusion,but the failure rate of immune system was 22.10%(29/131).CONLUSION The hepatitis B vaccine combined with immunoglobulin to block the mother-to-child transmission of hepatitis B has been implemented well,and the effect of blocking the vertical transmission of hepatitis B virus by HBsAg-positive mothers was significant.

关 键 词：乙肝 母婴阻断 措施 效果观察 

分 类 号：R714[医药卫生—妇产科学]