冻融过程诱导精子凋亡及抗冻保护剂的研究进展  

Research Progress on Sperm Apoptosis Induced by Freezing and Thawing Process and Cryoprotectants

作　　者：耿欣 郭勇[1] 陈余 王梁 倪和民[1] 盛熙晖[1] 王相国[1] 邢凯 肖龙菲 齐晓龙[1] GENG Xin;GUO Yong;CHEN Yu(School of Animal Science and Technology,Beijing Agricultural College,Beijing 102206;Beijing Animal Husbandry Station,Beijing 100107)

机构地区：[1]北京农学院动物科学技术学院,北京102206 [2]北京市畜牧总站,北京100107

出　　处：《安徽农业科学》2022年第3期19-21,25,共4页Journal of Anhui Agricultural Sciences

基　　金：现代农业产业技术体系北京市家禽创新团队项目(BAIC04-2020);“十三五”国家重点研发计划(2016YFD0700201);2020年农业科技项目-科技创新服务能力建设-农业科技新星计划项目(20200210);北京市农委“菜篮子”新型生产经营主体科技能力提升工程(2018)。

摘　　要：精子凋亡广泛存在于精液冻融过程,冷应激或氧化应激刺激及获能样变化均可引起精子凋亡。产生凋亡样变化的精子其结构、线粒体功能、膜电位、DNA完整性和参与凋亡反应的蛋白均发生变化,导致精子死亡率升高,活率下降。简述了冻融过程中精子凋亡的成因及抗冻保护剂的研究进展,以期为进一步提高冻融后的精子质量提供理论参考。Sperm apoptosis is widespread in the process of semen freezing and thawing.Cold stress or oxidative stress stimulation and capacitation-like changes can cause sperm apoptosis.The sperm with apoptosis-like changes changes in its structure,mitochondrial function,membrane potential,DNA integrity,and proteins involved in the apoptotic response,resulting in increased sperm mortality and decreased sperm viability.This paper briefly describes the causes of sperm apoptosis during freezing and thawing and the research progress of cryoprotectants,in order to provides a theoretical reference for further improving the quality of sperm after freezing and thawing.

关 键 词：精子 冻融过程 凋亡 抗冻保护剂 研究进展 

分 类 号：S814[农业科学—畜牧学]