TB水相催化手性α-羟基磷酸酯的合成  

Synthesis of Chiral α-Hydroxy phosphonates Catalyzed by TB in Water

作　　者：史晶晶[1] 徐长亮[1] 苑睿[2] 吴翚[2] Shi Jingjing;Xu Changliang;Yun Rui;Wu Hui(Jiangsu Food&Pharmaceutical Science College,Huaian 223005;Jiangsu Normal University,Xuzhou 221116,China)

机构地区：[1]江苏食品药品职业技术学院,江苏淮安223005 [2]江苏省药用植物生物技术重点实验室,江苏师范大学,江苏徐州221116

出　　处：《广东化工》2022年第4期27-28,34,共3页Guangdong Chemical Industry

基　　金：江苏省苏北科技专项项目(SZ-HA2019007);中药材中重金属离子快速检测探针的设计与研究。

摘　　要：羟基磷酸酯是极具吸引力的一类具有生物活性化合物,也是重要中间体。Aldol反应在反应中同时生成两个邻接手性中心,因此,该反应是构建不对称C-C键最简单、有效的一类化学转化方法。在TB的水相催化下,以靛红与亚磷酸三乙酯为原料,经Aldol反应合成一种手性α-羟基磷酸酯。结果表明,在温和的反应条件下,反应能够顺利进行,并且有很好的产率(91%)和ee值(92%)。Hydroxy phosphonate is an extremely attractive class of biologically active compounds and important intermediates. Aldol reaction is the simplest and most effective method of chemical transformation to construct asymmetric C-C bonds, which generates two adjacent chiral centers simultaneously. The synthesis of chiral α-hydroxyphosphonates is reported for Aldol reaction using isatin and triethyl phosphite as raw materials, catalyzed by TB in water. The reaction proceeded smoothly under mild reaction conditions. The resulting products were obtained with high yields(up to 91 %) and ee(up to 92 %).

关 键 词：TB 靛红 α-羟基磷酸酯 催化 手性 

分 类 号：TQ225.24[化学工程—有机化工]