氯吡格雷与低剂量替格瑞洛治疗不稳定型心绞痛效果对比  

Comparison of the Effect of Clopidogrel and Low-dose Ticagrelor in the Treatmentof Unstable Angina Pectoris

作　　者：汤峰文 韩腾姣 王会宾[1] Tang Wenfeng;Han Tengjiao;Wang Huibin(Department of Cardiology,Yanling County People's Hospital,Xuchang,Henan Province,Xuchang 461200)

机构地区：[1]河南省许昌市鄢陵县人民医院心内科,许昌461200

出　　处：《数理医药学杂志》2022年第2期212-214,共3页Journal of Mathematical Medicine

摘　　要：目的:对比氯吡格雷与低剂量替格瑞洛治疗不稳定型心绞痛效果。方法:回顾性分析2019年1月~2019年12月期间于某院接受治疗的125例不稳定型心绞痛患者研究资料,将采用常规治疗+氯吡格雷治疗的40例患者纳入A组,将采用常规治疗+常规剂量替格瑞洛治疗的40例患者纳入B组,将采用常规治疗+低剂量替格瑞洛治疗的45例患者纳入C组。3组均连续治疗2个月,观察3组临床疗效,对比3组治疗1周时及治疗1个月时血小板抑制率,并记录3组治疗期间不良事件发生率。结果:B组、C组临床总有效率(95.00%)、(93.33%)高于A组(75.00%),差异有统计学意义(P<0.05);治疗1周及治疗1个月时,B组、C组血小板抑制率均高于A组,差异有统计学意义(P<0.05);C组不良事件发生率(4.44%)低于A组(25.00%)、B组(22.50%),差异有统计学意义(P<0.05)。结论:低剂量替格瑞洛治疗不稳定型心绞痛患者效果优于氯吡格雷,可快速起到抑制血小板作用,且不会增加不良事件发生率。Objective:To compare the effect of clopidogrel and low-dose ticagrelor in the treatment of unstable angina pectoris.Methods:The data of 125 patients with unstable angina pectoris treated in a hospital from January 2019 to December 2019 were retrospectively analyzed.40 patients with conventional treatment and clopidogrel treatment were included in group A,40 patients treated with conventional therapy and conventional dose of ticagrelor were divided into group B,and 45 patients treated with conventional therapy and low-dose ticagrelor were included in group C.The three groups were treated for 2 months continuously.The clinical efficacy of the three groups was observed.The platelet inhibition rate of the three groups at 1 week and 1 months after treatment was compared,and the incidence of adverse events in the three groups was recorded.Results:The total effective rate of group B(95.00%)and group C(93.33%)were higher than that of group A(75.00%),and the difference was statistically significant(P<0.05).After 1 week and 1 month of treatment,the platelet inhibition rate of group B and group C were higher than that of group A,and the difference was statistically significant(P<0.05).The incidence of adverse events in group C(4.44%)was lower than that in group A(25.00%)and group B(22.50%),and the difference was statistically significant(P<0.05).Conclusion:Low dose ticagrelor is better than clopidogrel in the treatment of patients with unstable angina pectoris,which can quickly inhibit platelet and does not increase the incidence of adverse events.

关 键 词：不稳定型心绞痛 氯吡格雷 低剂量替格瑞洛 不良事件发生率 

分 类 号：R541.4[医药卫生—心血管疾病]