钆塞酸二钠增强磁共振肝胆期直方图分析诊断肝纤维化  

Histogram Analysis of Gd-EOB-DTPA Enhanced MRI Hepatobiliary Phase for Diagnosing Liver Fibrosis

作　　者：邓耒娇 梁晓磊[1] 魏玉辉[1] 王一青[1] DENG Leijiao;LIANG Xiaolei;WEI Yuhui(The First Hospital of Lanzhou University, Gansu Lanzhou 730000, China)

机构地区：[1]兰州大学第一医院药剂科,甘肃兰州730000

出　　处：《河北医学》2022年第2期230-235,共6页Hebei Medicine

基　　金：甘肃省杰出青年基金,(编号:18JR3RA262)。

摘　　要：目的:探究基于钆塞酸二钠(Gd-EOB-DTPA)增强磁共振肝胆期成像的直方图分析诊断肝纤维化(Liver fibrosis,LF)的价值。方法:回顾性分析经肝脏穿刺活检病理证实的83例LF患者的肝胆期磁共振图像,采用MaZda软件勾画全肝最大层面感兴趣区进行直方图分析,获取最小值、最大值、平均值、偏度、峰度、方差及百分位数(nth),并通过受试者工作特征曲线(ROC)分析不同LF分期的参数值差异性。结果:共纳入83例患者,F0期17例,F1、F2、F3和F4期分别有15、21、16和14例。直方图参数值90th(r=0.554),方差(r=0.484)、平均值(r=0.387)、50th(r=0.347)、峰度(r=0.279)和99th(r=0.255)与LF进展呈正相关(P<0.05)。参数值90th鉴别诊断LF的价值最高,诊断≥F1、≥F2、≥F3、F4的AUC值分别为0.79、0.78、0.76、0.82。结论:基于Gd-EOB-DTPA增强磁共振肝胆期直方图分析对预测LF进展、鉴别诊断具有较高的价值,可作为无创评估LF的有效影像学方法。Objective:To explore the value of histogram analysis based on Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DPTA)enhanced MRI hepatobiliary phase in diagnosing and staging liver fibrosis(LF).Methods:Hepatobiliary phase image of 83 patients with pathologically confirmed LF were retrospectively reviewed.MaZda software was used to extract histogram analysis parameters including minimum,maximum,mean,skewness,kurtosis,variance,and nth percentiles.Parameters were compared among different LF stages using receivers operating characteristic curve.Results:Eighty-three patients were included,and 17,15,21,16,and 14 cases were pathologically diagnosed as F0-F4,respectively.Histogram analysis parameters including the 90th(r=0.554),variance(r=0.484),mean(r=0.387),50th(r=0.347),kurtosis(r=0.279)and 99th parameter(r=0.255)of hepatobiliary phase demonstrated significant positive correlation with increasing fibrosis stage(P<0.05).The 90th parameter demonstrated higher diagnostic efficacy than other histogram analysis parameters in fibrosis staging,with an AUC value of 0.79 for≥F1,0.78 for≥F2,0.76 for≥F3,and 0.82 for≥F4,respectively.Conclusion:Histogram analysis of Gd-EOB-DPTA enhanced MRI hepatobiliary phase provides higher diagnostic value in predicting LF progression and distinguishing LF stages,which may be served as effective imaging alternative in staging HF.

关 键 词：钆塞酸二钠 肝胆期 直方图 肝纤维化 

分 类 号：R44[医药卫生—诊断学]