血栓弹力图与传统凝血指标对妊娠期糖尿病孕妇凝血功能的监测价值比较  

Comparison of the Values of Thromboelastogram and Traditional Coagulation Index in Monitoring Coagulation Function of Pregnant Women with Gestational Diabetes Mellitus

作　　者：张杨 钟家宁 郑英 胡华钟 ZHANG Yang(The Third Affiliated Hospital of Southern Medical University, Guangong Guangzhou 510630, China)

机构地区：[1]南方医科大学第三附属医院输血科,广东广州510630 [2]广东省广州市天河区中医院体检中心,广东广州510655

出　　处：《河北医学》2022年第2期263-267,共5页Hebei Medicine

基　　金：广东省医学科学技术研究基金项目,(编号:A2020387)。

摘　　要：目的:对比血栓弹力图与传统凝血指标对妊娠期糖尿病(GDM)孕妇凝血功能的监测价值。方法:选取2019年1月至2020年11月我院收治的86例GDM患者作为观察组,将同期常规孕检的70名健康孕妇作为对照组,两组均接受传统凝血指标检测与血栓弹力图(TEG)监测,对比两组各项检测结果,分析TEG与传统凝血指标的相关性。结果:观察组纤维蛋白原(FIB)、血小板(PLT)高于对照组,活化部分凝血酶时间(APTT)低于对照组,组间差异经统计学检验显示P<0.05,但两组在凝血酶原时间(PT)、D-二聚体(D-D)方面的差异无统计学意义(P>0.05);观察组患者凝血时间(K值)、反应时间(R值)低于对照组,Angle、最大振幅(MA)及凝血综合指数(CI值)高于对照组,差异有统计学意义(P<0.05);Pearson相关性分析显示Pearson相关性分析显示PLT、FIB与K值负相关,与Angle、MA、CI值呈现出明显正相关(P<0.05)。结论:TEG指标能够反映出GDM孕妇凝血功能情况,较传统凝血指标预测价值更高,可作为凝血功能指标监测的辅助手段,为GDM孕妇早期治疗提供参考。Objective:To compare the monitoring value of thrombolysis and traditional coagulation indexes in pregnant women with gestational diabetes mellitus(GDM).Methods:A total of 86 GDM patients admitted to our hospital between January 2019 and November 2020 were selected as observation group,and 70 healthy pregnant women in the same period for pregnancy test were selected as control group.Both groups had traditional coagulation indexes and thrombus elastic graph(TEG)monitoring,the test results were compared and correlation of TEG and traditional coagulation index was analyzed.Results:Fibrinogen(FIB)and platelet(PLT)in the observation group were higher than those in the control group,and activated partial thrombin time(APTT)was lower than that in the control group,between-group variance showed P<0.05,but there were no significant differences in prothrombin time(PT)and D-dimer(D-D)between the two groups(P>0.05);the coagulation time(K value)and reaction time(R value)in observation group were lower than those in control group,while the Angle,maximum amplitude(MA)and coagulation composite index(CI value)in observation group were higher than those in control group,and the differences were statistically significant(P<0.05);Pearson correlation analysis showed that PLT and FIB were negatively correlated with K,and positively correlated with Angle,MA and CI(P<0.05).Conclusion:TEG index can reflect the coagulation function of pregnant women with GDM,and has higher predictive value than traditional coagulation indexes,which can be used as an auxiliary means for monitoring coagulation function indexes and provide reference for the early treatment of pregnant women with GDM.

关 键 词：血栓弹力图 传统凝血指标 妊娠期糖尿病 凝血功能 相关性 

分 类 号：R71[医药卫生—妇产科学]